Kaplanskiĭ A S, Durnova G N, Sakharova Z F, Morukov B V
Kosm Biol Aviakosm Med. 1987 Jan-Feb;21(1):47-51.
Using histomorphometric methods, the effect of diphosphonates (hydroxydimethylaminopropylene diphosphonic acid and hydroxyethylene diphosphonic acid) on the development of osteoporosis in spongy matter of tibia and vertebrae of the rats exposed to hypokinesia for 60 days was investigated. It was found that aminopropylene diphosphonic acid in the dose 6 mg phosphorus/kg/day prevented osteoporosis and caused an increase in the volume density and abnormal (cartilage rich and poorly ossified) spongy bone. By contrast, ethylene diphosphonic acid in the dose 9 mg phosphorus/kg/day did not prevent osteoporosis but reduced its severity.
采用组织形态计量学方法，研究了双膦酸盐（羟二甲基氨基丙基二膦酸和羟基亚乙基二膦酸）对60天制动大鼠胫骨和椎骨松质骨骨质疏松症发展的影响。结果发现，剂量为6毫克磷/千克/天的氨基丙基二膦酸可预防骨质疏松症，并使骨体积密度增加，且导致异常（富含软骨且骨化不良）的松质骨增多。相比之下，剂量为9毫克磷/千克/天的亚乙基二膦酸不能预防骨质疏松症，但可减轻其严重程度。
