Shvets V N, Pankova A S
Kosm Biol Aviakosm Med. 1989 Jan-Feb;23(1):27-31.
The preventive effect of alpha-hydroxydimethyl-gamma-aminopropylidene bis-phosphonate was investigated histomorphometrically. The agent was injected subcutaneously to rats before hypokinesia at a dose of 5 mg/kg or during 35-day hypokinesia at a dose of 0.005 or 0.01 mg/kg daily. Regardless of the treatment protocol, the agent prevented osteoporosis and did not affect the epiphyseal growth plate. The agent modified significantly the bone cell count: osteoblasts decreased and osteoclasts increased. It is concluded that when compared to xydiphone (hydroxyethylidene bis-phosphoric acid), the agent proves several hundred times more effective. It is assumed that the agent modifies the relation between bone formation and bone resorption. Its osteotropic effect manifests as inhibition of bone resorption.
采用组织形态计量学方法研究了α-羟基二甲基-γ-氨丙基亚丙基双膦酸盐的预防效果。在大鼠运动减少前，以5mg/kg的剂量皮下注射该药物，或在35天的运动减少期间，每天以0.005或0.01mg/kg的剂量皮下注射。无论治疗方案如何，该药物均可预防骨质疏松，且不影响骨骺生长板。该药物显著改变了骨细胞计数：成骨细胞减少，破骨细胞增加。结论是，与羟乙膦酸钠（羟基亚乙基双膦酸）相比，该药物的效果要高出数百倍。据推测，该药物改变了骨形成与骨吸收之间的关系。其促骨作用表现为对骨吸收的抑制。
