Shvets V N, Pankova A S, Kabitskaia O E
Kosm Biol Aviakosm Med. 1988 Jul-Aug;22(4):65-70.
During 7 days prior to hypokinesia male Wistar rats were given 10 mg/kg xydiphone to ensure and additional bone pool. Then the rats were exposed to 32-day hypokinesia during which they were injected with 1 or 5 mg/kg xydiphone. Drug administration before hypokinesia prevented spongy bone losses in long bones, torso and pelvic bones. Xydiphone injections before and during hypokinesia not only prevented osteoporosis but also led to bone mass increase above the normal level. It is assumed that xydiphone stimulates the involvement of cells-precursors in the new bone formation. This method of osteoporosis prophylaxis can be recommended for space medicine application.
在低动力状态前7天，给雄性Wistar大鼠注射10mg/kg的昔多芬，以确保额外的骨储备。然后，大鼠经历32天的低动力状态，在此期间，它们被注射1或5mg/kg的昔多芬。低动力状态前给药可预防长骨、躯干骨和骨盆骨的松质骨流失。在低动力状态前和期间注射昔多芬不仅可以预防骨质疏松症，还会使骨量增加至正常水平以上。据推测，昔多芬可刺激前体细胞参与新骨形成。这种骨质疏松症预防方法可推荐用于航天医学。
