Shvets V N
Kosm Biol Aviakosm Med. 1988 Jan-Feb;22(1):34-7.
For 10 days rats were subcutaneously injected with alpha-hydroxydimethyl-gamma-aminopropylidene biphosphonate in the dose range 0.005 to 5 mg/kg/day. As shown morphometrically, the mass of spongy bone increased linearly with the dose. It was found that the drug affected primarily the highly metabolic component of spongy bone. The drug had a systemic osteotrophic effect and modified the number of osteocytes significantly. When the drug was injected for a long time (up to 60 days), the number of osteoclasts decreased and the proportion of cells containing more than one nucleus remained within normal limits. The number of osteoblasts either diminished (in long bones) or remained unchanged (in torso and pelvic bones). It is concluded that the osteotrophic effect of the drug is mediated via its action on bone resorption the rate of which is inhibited; this is responsible for bone mass growth.
连续10天给大鼠皮下注射α-羟基二甲基-γ-氨丙基亚甲基双膦酸盐，剂量范围为0.005至5毫克/千克/天。形态测量结果显示，松质骨质量随剂量呈线性增加。发现该药物主要影响松质骨的高代谢成分。该药物具有全身骨营养作用，并显著改变了骨细胞数量。当长期（长达60天）注射该药物时，破骨细胞数量减少，多核细胞比例保持在正常范围内。成骨细胞数量在长骨中减少，在躯干骨和骨盆骨中保持不变。结论是，该药物的骨营养作用是通过其对骨吸收的作用介导的，骨吸收速率受到抑制，这导致了骨量增加。
