Le Page P A, Furtado R, Hayward M, Law S, Tan A, Vivian S J, Van der Wall H, Falk G L
1 Concord Repatriation General Hospital, NSW , Australia.
2 University of Sydney, NSW , Australia.
Ann R Coll Surg Engl. 2015 Apr;97(3):188-93. doi: 10.1308/003588414X14055925060839.
The surgical management of symptomatic giant hiatus hernia (GHH) aims to improve quality of life (QoL) and reduce the risk of life threatening complications. Previous reports are predominantly those with small sample sizes and short follow-up periods. The present study sought to assess a large cohort of patients for recurrence and QoL over a longer time period.
This was a follow-up study of a prospectively collected database of 455 consecutive patients. Primary repair of GHH was evaluated by endoscopy/barium meal for recurrence and a standardised symptom questionnaire for QoL. Recurrence was assessed for size, elapsed time, oesophagitis and symptoms.
Objective and subjective review was achieved in 91.9% and 68.6% of patients. The median age was 69 years (range: 15-93 years) and 64% were female. Laparoscopic repair was completed in 95% (mesh in 6% and Collis gastroplasty in 7%). The 30-day mortality rate was 0.9%. The proportion of patients alive at five and ten years were 90% and 75% respectively. Postoperative QoL scores improved from a mean of 95 to 111 (p<0.01) and were stable over time (112 at 10 years). The overall recurrence rate was 35.6% (149/418) at 42 months; this was 11.5% (48/418) for hernias >2cm and 24.2% (101/418) for <2cm. The rate of new recurrence at 0-1 years was 13.7% (>2cm = 3.4%, <2cm = 10.3%), at 1-5 years it was 30.8% (>2cm = 9.5%, <2cm = 21.3%), at 5-10 years it was 40.1% (>2cm = 13.8%, <2cm = 26.3%) and at over 10 years it was 50.0% (>2cm = 25.0%, <2cm = 25.0%). Recurrence was associated with oesophagitis but not decreased QoL. Revision surgery was required in 4.8% of cases (14.8% with recurrence). There were no interval major GHH complications.
Surgery has provided sustained QoL improvements irrespective of recurrence. Recurrence occurred progressively over ten years and may predispose to oesophagitis.
有症状的巨大食管裂孔疝(GHH)的外科治疗旨在改善生活质量(QoL)并降低危及生命的并发症风险。以往的报告大多样本量小且随访期短。本研究旨在评估一大群患者在较长时间段内的复发情况和生活质量。
这是一项对前瞻性收集的455例连续患者数据库的随访研究。通过内镜检查/钡餐评估GHH的初次修复情况以判断复发,并使用标准化症状问卷评估生活质量。对复发的大小、时间、食管炎和症状进行评估。
分别有91.9%和68.6%的患者完成了客观和主观评估。中位年龄为69岁(范围:15 - 93岁),64%为女性。95%的患者完成了腹腔镜修复(6%使用补片,7%进行科利斯胃成形术)。30天死亡率为0.9%。5年和10年存活患者的比例分别为90%和75%。术后生活质量评分从平均95分提高到111分(p<0.01),且随时间保持稳定(10年时为112分)。42个月时总体复发率为35.6%(149/418);疝囊>2cm者复发率为11.5%(48/418),<2cm者为24.2%(101/418)。0 - 1年新复发率为13.7%(>2cm = 3.4%,<2cm = 10.3%),1 - 5年为30.8%(>2cm = 9.5%,<2cm = 21.3%),5 - 10年为40.1%(>2cm = 13.8%,<2cm = 26.3%),超过10年为50.0%(>2cm = 25.0%,<2cm = 25.0%)。复发与食管炎相关,但与生活质量下降无关。4.8%的病例需要再次手术(复发患者中为14.8%)。期间未发生重大GHH并发症。
无论是否复发,手术均持续改善了生活质量。复发在十年间逐渐发生,且可能易导致食管炎。