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股骨颈髋关节假体植入后的骨密度——一项为期5年的前瞻性随访研究

Bone mineral density after implantation of a femoral neck hip prosthesis--a prospective 5 year follow-up.

作者信息

Steens Wolfram, Boettner Friedrich, Bader Rainer, Skripitz Ralf, Schneeberger Alberto

机构信息

Department of Orthopedics, University Medicine Rostock, 18057, Rostock, Germany.

Hospital for Special Surgery, New York, NY, USA.

出版信息

BMC Musculoskelet Disord. 2015 Aug 12;16:192. doi: 10.1186/s12891-015-0624-0.

Abstract

BACKGROUND

Bone resorption in the proximal femur due to stress shielding has been observed in a number of conventional cementless implants used in total hip arthroplasty. Short femoral-neck implants are claiming less interference with the biomechanics of the proximal femur. The goal of this study was to prospectively investigate the in vivo changes of bone-mineral density as a parameter of bone remodeling around a short, femoral neck prosthesis over the first 5 years following implantation. The secondary goal was to report on its clinical outcome.

METHODS

We are reporting on the changes of bone mineral density of the proximal femur and the clinical outcome up to five years after implantation of a short femoral neck prosthesis. Bone mineral density was determined using dual energy x-ray absorptiometry, performed 10 days, three, 12 and 60 months after surgery. 20 patients with a mean age of 47 years (range 17 to 65) were clinically assessed using the Harris Hip Score. The WOMAC was used as a patient-relevant outcome-measure.

RESULTS

In contrast to conventional implants DEXA-scans overall revealed a slight increase of bone mineral density in the proximal femur in the 12 months following the implantation. The Harris Hip Score improved from an average preoperative score of 46 to a postoperative score at 12 months of 91 points and 95 points at 60 months, the global WOMAC index from 5.3 preoperatively to 0.8 at 12 months and 0.6 at 60 months postoperatively.

CONCLUSION

At 60 months after implantation of a short femoral neck prosthesis, all regions except one (region of interest #5) showed no significant changes in BMD compared to baseline measurements at 10 days which is less to the changes in bone mineral density seen in conventional implants.

摘要

背景

在全髋关节置换术中使用的许多传统非骨水泥型植入物中,均观察到由于应力遮挡导致股骨近端骨吸收。短股骨颈植入物对股骨近端生物力学的干扰较小。本研究的目的是前瞻性调查植入后前5年,作为短股骨颈假体周围骨重塑参数的骨矿物质密度的体内变化。次要目的是报告其临床结果。

方法

我们报告了短股骨颈假体植入后长达五年的股骨近端骨矿物质密度变化及临床结果。使用双能X线吸收法在术后10天、3个月、12个月和60个月测定骨矿物质密度。采用Harris髋关节评分对20例平均年龄47岁(范围17至65岁)的患者进行临床评估。使用WOMAC作为与患者相关的结局指标。

结果

与传统植入物相比,DEXA扫描总体显示植入后12个月股骨近端骨矿物质密度略有增加。Harris髋关节评分从术前平均46分提高到术后12个月的91分和60个月时的95分,整体WOMAC指数从术前的5.3提高到术后12个月的0.8和60个月时的0.6。

结论

在短股骨颈假体植入60个月后,除一个区域(感兴趣区域#5)外,所有区域与术后10天的基线测量相比,骨密度均无显著变化,这低于传统植入物中观察到的骨矿物质密度变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6abc/4534108/342c00a59b3e/12891_2015_624_Fig1_HTML.jpg

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