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维生素D和钙补充剂在牙周炎治疗中的作用

Influence of Vitamin D & Calcium Supplementation in the Management of Periodontitis.

作者信息

Perayil Jayachandran, Menon Keerthy S, Kurup Seema, Thomas Anju Elizebath, Fenol Angel, Vyloppillil Rajesh, Bhaskar Anuradha, Megha Sai

机构信息

Professor and HOD, Department of Periodontics, Amrita School of Dentistry , Ponekkara, Kochi, India .

Post Graduate Trainee, Department of Periodontics, Amrita School of Dentistry , Ponekkara, Kochi, India .

出版信息

J Clin Diagn Res. 2015 Jun;9(6):ZC35-8. doi: 10.7860/JCDR/2015/12292.6091. Epub 2015 Jun 1.

Abstract

INTRODUCTION

It has long been recognized that vitamin D is a hormone and were many studies reporting that patients in periodontal maintenance programs taking vitamin D and calcium supplementation had a trend for better periodontal health compared to patients not taking supplementation.

AIM

To evaluate the effect of vitamin D and calcium supplementation in reducing gingival inflammation, using clinical parameters like gingival index (GI), oral hygiene index-simplified (OHIS), probing pocket depth (PPD), clinical attachment level (CAL) and bone density (BD). Also, to assess whether calcium and vitamin D oral supplementation influences alveolar Bone Density (BD).

DESIGN AND SETTINGS

A nonrandomised clinical trial done in Amrita School of dentistry, Kochi, India.

MATERIALS AND METHODS

Group A taking vitamin D (250IU/day) and calcium (500 mg/day) supplementation, and Group B were not taking oral supplementation. All subjects had at least one or more teeth with chronic moderate periodontitis. Digital Orthopantomogram images were taken to assess bone density. Data were collected at baseline and three months.

STATISTICAL ANALYSIS USED

OHI-S, GI, PPD, CAL, and Bone Densities (BD) were calculated per group. Karl Pearson Coefficient of correlation was used to test correlation of bone density with GI and OHI -S. Intergroup comparison of parameters were done using Independent two Sample t-test. Intragroup comparison of parameters at recall interval was done using Paired sample t-test. The results were considered statistically significant when p-value was <0.05.

RESULTS

Both Groups showed significant change in the periodontal parameters and bone density after three months and intragroup comparison showed highly significant results for vitamin D group in relation to GI, OHI S and bone density.

CONCLUSION

Calcium and vitamin D supplementation has got a positive effect on periodontal health and it can be used as an adjunct to non surgical periodontal therapy.

摘要

引言

长期以来,人们一直认为维生素D是一种激素,许多研究报告称,与未服用补充剂的患者相比,参加牙周维护计划并服用维生素D和钙补充剂的患者的牙周健康状况有改善的趋势。

目的

使用牙龈指数(GI)、简化口腔卫生指数(OHIS)、探诊袋深度(PPD)、临床附着水平(CAL)和骨密度(BD)等临床参数,评估维生素D和钙补充剂在减轻牙龈炎症方面的作用。此外,评估口服钙和维生素D补充剂是否会影响牙槽骨密度(BD)。

设计与地点

在印度科钦的阿姆瑞塔牙科学院进行的一项非随机临床试验。

材料与方法

A组服用维生素D(250IU/天)和钙(500毫克/天)补充剂,B组未进行口服补充。所有受试者至少有一颗或多颗牙齿患有慢性中度牙周炎。拍摄数字化曲面断层图像以评估骨密度。在基线和三个月时收集数据。

所用统计分析方法

计算每组的OHI-S、GI、PPD、CAL和骨密度(BD)。使用卡尔·皮尔逊相关系数检验骨密度与GI和OHI-S的相关性。使用独立两样本t检验进行参数的组间比较。使用配对样本t检验进行召回间隔时参数的组内比较。当p值<0.05时,结果被认为具有统计学意义。

结果

两组在三个月后牙周参数和骨密度均有显著变化,组内比较显示维生素D组在GI、OHI-S和骨密度方面有高度显著的结果。

结论

补充钙和维生素D对牙周健康有积极作用,可作为非手术牙周治疗的辅助手段。

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