Department of Periodontology, New Horizon Dental College, Bilaspur, 495001 Chattisgarh, India.
Department of Periodontology, SRM Kattankulathur Dental College & Hospital, SRM lnstitute of Science and Technology, SRM Nagar, Kattankulathur, 603203 Kancheepuram, Chennai, Tamil Nadu, India.
Biomed Res Int. 2022 Aug 8;2022:5869676. doi: 10.1155/2022/5869676. eCollection 2022.
Vitamin D has anti-inflammatory properties and the potential to increase the generation of antimicrobial peptides like cathelicidin and defensins that may have a good impact on oral health. Higher vitamin D consumption has also been linked to a reduced risk of periodontal disease progression. Hence, the primary objective of this study was to evaluate and compare the clinical and laboratory parameters of oral supplementation of vitamin D as an adjuvant to scaling and root planing and to assess the bone mineral density via qualitative ultrasound bone density scanner in chronic periodontitis patients. . This study included 40 patients with periodontitis categorized into 2 groups with twenty patients each, Group I comprising scaling and root planing (SRP) alone and Group II comprising SRP along with vitamin D supplementation. Plaque index, gingival index, probing pocket depth, and clinical attachment loss was measured as clinical parameters. Serum vitamin D levels were assessed before and after SRP at both baseline and 6 weeks.
The intergroup comparison of clinical parameters (PI, GI, PPD, and CAL) at 6 weeks for both the groups showed statistical significance. Intragroup comparison of clinical parameters from baseline to 6 weeks showed a statistically significant reduction in both groups. The mean bone mineral density level in both the control and test groups demonstrated a mean score of -1.3 and -1.21, respectively. The mean vitamin D levels were 27.8460 and 28.1020 for the test and control groups, respectively, which was statistically insignificant ( = 0.705) and those at six-week intervals improved to 31.3650 and 28.0240 which were statistically significant ( ≤ 0.001).
It could be stated that a positive relationship exists between periodontitis and osteopenia which could aggravate periodontal destruction. All periodontitis cases should thus be evaluated for BMD and supplemented with vitamin D in an appropriate dosage and time frame to treat both these diseases.
维生素 D 具有抗炎特性，并有可能增加抗菌肽（如 cathelicidin 和 defensins）的生成，这可能对口腔健康有很好的影响。更高的维生素 D 摄入也与牙周病进展风险降低有关。因此，本研究的主要目的是评估和比较维生素 D 口腔补充作为龈下刮治和根面平整辅助治疗的临床和实验室参数，并通过定性超声骨密度扫描仪评估慢性牙周炎患者的骨矿物质密度。
这项研究包括 40 名牙周炎患者，分为两组，每组 20 名患者。第 I 组仅接受龈下刮治和根面平整（SRP）治疗，第 II 组接受 SRP 联合维生素 D 补充治疗。将菌斑指数、牙龈指数、探诊袋深度和临床附着丧失作为临床参数进行测量。在基线和 6 周时，分别在 SRP 前后评估血清维生素 D 水平。
两组在 6 周时的临床参数（PI、GI、PPD 和 CAL）的组间比较显示有统计学意义。两组从基线到 6 周的临床参数的组内比较显示有统计学意义的降低。两组的平均骨矿物质密度水平分别为 -1.3 和 -1.21。测试组和对照组的平均维生素 D 水平分别为 27.8460 和 28.1020，无统计学意义（ = 0.705），而在 6 周的间隔内，分别提高到 31.3650 和 28.0240，有统计学意义（ ≤ 0.001）。
可以说，牙周炎和骨质疏松症之间存在正相关关系，这可能会加重牙周破坏。因此，所有牙周炎病例都应评估 BMD，并在适当的剂量和时间框架内补充维生素 D，以治疗这两种疾病。
