肝干细胞：实验研究结果及其对人类肝脏疾病的意义
Liver Stem Cells: Experimental Findings and Implications for Human Liver Disease.
作者信息
Michalopoulos George K, Khan Zahida
机构信息
Department of Pathology University of Pittsburgh School of Medicine.
Department of Pediatric Gastroenterology University of Pittsburgh School of Medicine.
出版信息
Gastroenterology. 2015 Oct;149(4):876-882. doi: 10.1053/j.gastro.2015.08.004. Epub 2015 Aug 14.
Abstract
Evidence from human histopathology and experimental studies with rodents and zebrafish has shown that hepatocytes and cholangiocytes may function as facultative stem cells for each other in conditions of impaired regeneration. The interpretation of the findings derived from these studies has generated considerable discussion and some controversies. This review examines the evidence obtained from the different experimental models and considers implications that these studies may have for human liver disease.
摘要
来自人类组织病理学以及对啮齿动物和斑马鱼的实验研究的证据表明，在再生受损的情况下，肝细胞和胆管细胞可能互为兼性干细胞。对这些研究结果的解读引发了大量讨论和一些争议。本综述审视了从不同实验模型中获得的证据，并探讨了这些研究可能对人类肝脏疾病产生的影响。
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