Ramenghi U, David O, Dianzani I, Sacchetti L, Biasi F, Chiarpotto E, Poli G
Haematologica. 1989 Nov-Dec;74(6):531-5.
Several carbonyls more toxic than malonaldehyde (MDA) are also generated during the propagation of lipid peroxidation stimulated "in vitro" in human erythrocytes. As regards thalassaemia, after "in vitro" treatment with tert-butyl hydroperoxide (TBHP), the total amount of aldehydes formed (MDA plus the other carbonyls) is significantly increased in the red cells from homozygous as compared to heterozygous and normal subjects. These findings lead to the conclusion that the extent of lipid peroxidation in erythrocytes is actually wider than that measurable in terms of malonaldehyde only, and that aldehydes of the hydroxyalkenal class in particular may play a role in the pathogenesis of reduced red cell survival in haemolytic anaemias.
在人红细胞“体外”刺激的脂质过氧化过程中，还会产生几种比丙二醛（MDA）毒性更强的羰基化合物。关于地中海贫血，在用叔丁基过氧化氢（TBHP）进行“体外”处理后，与杂合子和正常受试者相比，纯合子红细胞中形成的醛总量（MDA加上其他羰基化合物）显著增加。这些发现得出的结论是，红细胞中脂质过氧化的程度实际上比仅以丙二醛衡量的范围更广，特别是羟基烯醛类醛可能在溶血性贫血中红细胞存活期缩短的发病机制中起作用。
