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参加戒烟计划的受试者1年随访中的复发率及与复发相关的因素

Relapse Rate and Factors Related to Relapse in a 1-Year Follow-Up of Subjects Participating in a Smoking Cessation Program.

作者信息

Koçak Nagihan Durmuş, Eren Ayşegül, Boğa Sibel, Aktürk Ülkü Aka, Öztürk Ülkem Angın, Arınç Sibel, Şengül Aysun

机构信息

Department of Pulmonary Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.

Department of Psychiatric Diseases, Süreyyapaşa Chest Diseases and Thoracic Surgery Education and Research Hospital, Istanbul, Turkey.

出版信息

Respir Care. 2015 Dec;60(12):1796-803. doi: 10.4187/respcare.03883. Epub 2015 Aug 18.

Abstract

BACKGROUND

The most important and difficult task when it comes to reducing tobacco-related morbidity and mortality is to convince smokers to quit and to maintain their abstinence. This study aimed to determine the smoking relapse rate and factors related to relapse in subjects who participated in a smoking cessation program and completed a 1-y follow-up in our center.

METHODS

The study included 550 subjects who applied to a smoking cessation clinic from June 1, 2011 to December 31, 2011 and completed the 1-y follow-up.

RESULTS

After 1 y, 282 (51.4%) subjects had relapsed, 132 (24%) had quit smoking, and 135 (24.6%) could not be contacted. The mean age ± SD was 41.5 ± 10.8 y, and 52.5% were male. There was no difference between non-relapsed and relapsed subjects with regard to age, sex, average smoking duration and daily number of cigarettes, reason to quit, education level, presence of symptoms and concomitant diseases, Fagerström nicotine dependence score, Beck depression score, and frequency of pharmacotherapy administration. In the relapsed group, the age began smoking was younger (P = .05), and the longest prior duration of abstinence was shorter (P = .04). The average number of support contacts was found to be significantly higher in the non-relapsed subjects (P < .001). Logistic regression analysis revealed alcohol intake to be a factor influencing relapse (odds ratio: 2.11, 95% CI: 1.13-3.93, P = .02), as was the number of support contacts (odds ratio: 2.06, 95% CI: 1.59-2.65, P < .001). The presence of drug adverse effects was close to being significant (odds ratio: 1.96, 95% CI: 0.93-4.10, P = .07).

CONCLUSION

The relapse rate in a 1-y period was 51.4%. Similar to previous studies, alcohol intake presented a relapse risk. In subjects receiving drug treatment, planning support meetings more frequently and paying attention to adverse effects may increase the success of smoking cessation.

摘要

背景

在降低烟草相关发病率和死亡率方面,最重要且最困难的任务是说服吸烟者戒烟并保持戒烟状态。本研究旨在确定参与戒烟项目并在本中心完成1年随访的受试者的吸烟复发率及与复发相关的因素。

方法

本研究纳入了2011年6月1日至2011年12月31日申请进入戒烟门诊并完成1年随访的550名受试者。

结果

1年后,282名(51.4%)受试者复发,132名(24%)戒烟成功,135名(24.6%)无法取得联系。平均年龄±标准差为41.5±10.8岁,男性占52.5%。在年龄、性别、平均吸烟时长、每日吸烟量、戒烟原因、教育水平、症状及伴发疾病的存在情况、法格斯特罗姆尼古丁依赖评分、贝克抑郁评分以及药物治疗给药频率方面,未复发组和复发组之间无差异。在复发组中,开始吸烟的年龄更小(P = 0.05),之前最长的戒烟时长更短(P = 0.04)。发现未复发受试者的平均支持联系次数显著更高(P < 0.001)。逻辑回归分析显示,饮酒是影响复发的一个因素(比值比:2.11,95%置信区间:1.13 - 3.93,P = 0.02),支持联系次数也是如此(比值比:2.06,95%置信区间:1.59 - 2.65,P < 0.001)。药物不良反应的存在接近显著水平(比值比:1.96,95%置信区间:0.93 - 4.10,P = 0.07)。

结论

1年期的复发率为51.4%。与先前研究相似,饮酒存在复发风险。在接受药物治疗的受试者中,更频繁地安排支持会议并关注不良反应可能会提高戒烟成功率。

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