Vesco Anthony T, Lehmann Jennifer, Gracious Barbara L, Arnold L Eugene, Young Andrea S, Fristad Mary A
1 Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center , Columbus, Ohio.
2 Department of Psychology, The Ohio State University , Columbus, Ohio.
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):526-34. doi: 10.1089/cap.2013.0141. Epub 2015 Aug 19.
Therapeutic benefits of omega-3 fatty acids (Ω3) for mood disorders, psychosis, and anxiety have been reported in the literature. The purpose of the present article is to provide a literature review of Ω3 supplementation for affective disorders and to illustrate the benefits of Ω3 with a case presentation of a young girl with a history of bipolar disorder-type 1 with psychotic features and generalized anxiety disorder.
Reviewed literature includes treatment studies of the impact of Ω3 on child mood disorders supplemented by review of meta-analyses within the adult mood disorders literature. The subject of this case report participated in 11 in-depth diagnostic and functional assessments over 5 years as part of an unrelated study. Three years were presupplementation and 2 years were with supplementation with no other medication changes, thus making a naturalistic multiple-baseline single-subject experiment.
Augmentation over a 2 year period was notable for clinically significant and sustained improvement in depressive, manic, and psychotic symptoms.
Ω3 supplementation may be a safe, adjunct intervention for treating bipolar disorder in children and adolescents, even in the presence of psychotic and anxious features. The 2 year follow-up in this case offers hope of an accumulating and enduring benefit. Further research into mechanisms of Ω3 action and of combination treatment with other well-known interventions for mood disorders would be beneficial.
文献报道了ω-3脂肪酸（Ω3）对情绪障碍、精神病和焦虑症的治疗益处。本文旨在对Ω3补充剂治疗情感障碍进行文献综述，并通过一个患有1型双相情感障碍伴精神病性特征和广泛性焦虑症的年轻女孩的病例介绍来说明Ω3的益处。
综述文献包括Ω3对儿童情绪障碍影响的治疗研究，并辅以对成人情绪障碍文献中荟萃分析的回顾。作为一项无关研究的一部分，该病例报告的受试者在5年中参与了11次深入的诊断和功能评估。3年为补充前，2年为补充期，期间未改变其他药物治疗，从而形成了一个自然主义的多基线单受试者实验。
在2年期间，抑郁、躁狂和精神病性症状在临床上有显著且持续的改善，这一点值得注意。
Ω3补充剂可能是治疗儿童和青少年双相情感障碍的一种安全的辅助干预措施，即使存在精神病性和焦虑特征。该病例的2年随访带来了累积和持久益处的希望。进一步研究Ω3的作用机制以及与其他治疗情绪障碍的知名干预措施联合治疗将是有益的。
