Meiman Jon, Thiboldeaux Robert, Anderson Henry
MMWR Morb Mortal Wkly Rep. 2015 Aug 21;64(32):883. doi: 10.15585/mmwr.mm6432a6.
On April 30, 2015, the Wisconsin Division of Public Health (WDPH) was notified by a local health department of an elevated blood lead level (BLL) in a female patient aged 64 years. All Wisconsin laboratories are required to provide BLL testing results performed on any state resident to WDPH, and WDPH and local health departments are statutorily mandated to investigate any single BLL ≥20 µg/dL or BLLs that are persistently ≥15 µg/dL. Review of medical records revealed that the patient had developed progressive fatigue and shortness of breath during a period of multiple weeks that prompted inpatient medical evaluation. Hemoglobin level was 8.3 g/dL (normal range for age and sex of patient = 12.5-15.0 g/dL), and peripheral blood smear showed normochromic, normocytic red blood cells with basophilic stippling. A BLL was obtained and found to be 85.8 µg/dL. Urine toxic metals tests revealed mercury and aluminum levels in the normal range. Combined methylated and inorganic urine arsenic levels were slightly elevated at 53.3 µg/L (normal = <18.9 µg/L). The patient was discharged for outpatient lead chelation therapy with oral meso-2,3-dimercaptosuccinic acid.
2015年4月30日,当地卫生部门向威斯康星州公共卫生部(WDPH)通报了一名64岁女性患者血铅水平(BLL)升高的情况。威斯康星州所有实验室都必须向WDPH提供对该州任何居民进行的BLL检测结果,并且根据法规,WDPH和当地卫生部门必须对任何单一BLL≥20μg/dL或持续≥15μg/dL的BLL进行调查。病历审查显示,该患者在数周内出现了进行性疲劳和呼吸急促,促使其进行住院医学评估。血红蛋白水平为8.3g/dL(患者年龄和性别的正常范围=12.5-15.0g/dL),外周血涂片显示正色素、正细胞性红细胞伴有嗜碱性点彩。检测发现BLL为85.8μg/dL。尿液有毒金属检测显示汞和铝水平在正常范围内。尿液中甲基化砷和无机砷的综合水平略有升高,为53.3μg/L(正常范围=<18.9μg/L)。该患者出院接受口服消旋-2,3-二巯基丁二酸的门诊驱铅治疗。