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西妥昔单抗治疗晚期头颈癌期间发生肠壁囊样积气症两例

Two Cases of Pneumatosis Intestinalis during Cetuximab Therapy for Advanced Head and Neck Cancer.

作者信息

Miller James A, Ford Daniel J, Ahmed Mohamed S, Loree Thom R

机构信息

The Center for Oncology Care, Erie County Medical Center, 462 Grider Street, ACC Building 2nd Floor, Buffalo, NY 14215, USA ; School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14214, USA.

The Center for Oncology Care, Erie County Medical Center, 462 Grider Street, ACC Building 2nd Floor, Buffalo, NY 14215, USA.

出版信息

Case Rep Oncol Med. 2015;2015:214236. doi: 10.1155/2015/214236. Epub 2015 Jul 29.

DOI:10.1155/2015/214236
PMID:26294992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4532904/
Abstract

Pneumatosis intestinalis is a rare but known potential complication of treatment with cetuximab. Here we present two cases of pneumatosis intestinalis occurring in patients who were receiving cetuximab as treatment for advanced head and neck cancer. In both cases, cetuximab was discontinued after discovery of the pneumatosis intestinalis.

摘要

肠壁积气是西妥昔单抗治疗罕见但已知的潜在并发症。在此，我们报告两例在接受西妥昔单抗治疗晚期头颈癌的患者中发生肠壁积气的病例。在这两例病例中，发现肠壁积气后均停用了西妥昔单抗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/1b25b0556a6e/CRIONM2015-214236.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/4161ea879fbe/CRIONM2015-214236.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/02664b782bd6/CRIONM2015-214236.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/1b25b0556a6e/CRIONM2015-214236.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/4161ea879fbe/CRIONM2015-214236.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/02664b782bd6/CRIONM2015-214236.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/297d/4532904/1b25b0556a6e/CRIONM2015-214236.003.jpg

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本文引用的文献

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2
Pneumatosis intestinalis and bowel perforation associated with molecular targeted therapy: an emerging problem and the role of radiologists in its management.肠气肿和肠穿孔与分子靶向治疗相关：一个新出现的问题和放射科医生在其管理中的作用。
AJR Am J Roentgenol. 2012 Dec;199(6):1259-65. doi: 10.2214/AJR.12.8782.
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BJR Case Rep. 2017 Jul 29;3(4):20170039. doi: 10.1259/bjrcr.20170039. eCollection 2017.
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Pneumatosis intestinalis during chemotherapy with nilotinib in a patient with chronic myeloid leukemia who tested positive for anti-topoisomerase I antibodies.一名慢性髓性白血病患者在使用尼罗替尼化疗期间发生肠壁积气，该患者抗拓扑异构酶I抗体检测呈阳性。
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Rev Med Brux. 2012 Jan-Feb;33(1):48-50.
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Pneumatosis intestinalis after cetuximab-containing chemotherapy for colorectal cancer.结直肠癌含西妥昔单抗化疗后出现肠积气。
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