Laroni Alice, de Rosbo Nicole Kerlero, Uccelli Antonio
Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Largo Daneo 3, 16132 Genoa, Italy; Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV, 5, 16132 Genoa, Italy.
Department of Neurology, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
Immunol Lett. 2015 Dec;168(2):183-90. doi: 10.1016/j.imlet.2015.08.007. Epub 2015 Aug 18.
An inflammatory response is often observed in neurological diseases, being characterized sometimes by activation of adaptive cells (T and B lymphocytes) and, almost inexorably, of cells of the innate immunity (microglial cells, macrophages). Mesenchymal stromal/stem cells represent a promising therapeutic approach for the treatment of intractable neurological diseases given the possibility that they affect neurodegeneration both directly and indirectly, through their potent immunomodulatory effect. Here we will review the evidence, mostly deriving from preclinical studies, that MSC, beyond their ability to foster neurorepair, can ameliorate neurodegenerative diseases through their effect on associated immune responses.
在神经疾病中常常观察到炎症反应，其特征有时是适应性细胞（T和B淋巴细胞）的激活，并且几乎不可避免地会激活先天免疫细胞（小胶质细胞、巨噬细胞）。鉴于间充质基质/干细胞有可能通过其强大的免疫调节作用直接和间接地影响神经退行性变，因此它们是治疗难治性神经疾病的一种有前景的治疗方法。在此，我们将综述主要来自临床前研究的证据，即间充质干细胞除了具有促进神经修复的能力外，还可以通过其对相关免疫反应的影响来改善神经退行性疾病。
