Cheng Meng-Chun, Tsai Tsung-Yu, Pan Tzu-Ming
Department of Biochemical Science & Technology, National Taiwan University, Taipei, Taiwan.
Food Funct. 2015 Nov;6(11):3522-30. doi: 10.1039/c5fo00531k. Epub 2015 Aug 24.
The anti-obesity activity of the water extract of soy milk fermented with Lactobacillus paracasei subsp. paracasei NTU 101 (W101) was investigated. A high-fat diet (HFD) was used to induce obesity in rats, and the effects of daily W101 feeding (8 weeks) were observed. The rats fed the HFD and supplemented with low-dose W101 (LW101, 15 mg per kg body weight per day) or high-dose W101 (HW101, 150 mg per kg body weight per day) had significantly reduced final body weight in comparison with that of the HFD group. W101 decreased the formation of lipid plaques in the aorta, reduced the adipocyte cross-sectional area and diameter, and reduced the levels of CCAAT/enhancer-binding protein β (C/EBPβ), peroxisome proliferator associated receptor γ (PPARγ), and C/EBPα. Regarding lipogenesis regulation in adipocytes, W101 suppressed heparin-releasable lipoprotein lipase (HR-LPL) in adipose tissues and inhibited lipid absorption, thereby reducing lipogenesis. Lactobacillus paracasei subsp. paracasei NTU 101-fermented soy milk may be used to develop health foods that prevent obesity.
研究了副干酪乳杆菌副干酪亚种NTU 101（W101）发酵豆浆水提取物的抗肥胖活性。采用高脂饮食（HFD）诱导大鼠肥胖，并观察每日喂食W101（8周）的效果。与HFD组相比，喂食HFD并补充低剂量W101（LW101，每天每千克体重15毫克）或高剂量W101（HW101，每天每千克体重150毫克）的大鼠最终体重显著降低。W101减少了主动脉中脂质斑块的形成，减小了脂肪细胞的横截面积和直径，并降低了CCAAT/增强子结合蛋白β（C/EBPβ）、过氧化物酶体增殖物激活受体γ（PPARγ）和C/EBPα的水平。关于脂肪细胞中的脂肪生成调节，W101抑制了脂肪组织中肝素可释放脂蛋白脂肪酶（HR-LPL）并抑制脂质吸收，从而减少脂肪生成。副干酪乳杆菌副干酪亚种NTU 101发酵豆浆可用于开发预防肥胖的健康食品。
