Vercauteren Koen, de Jong Ype P, Meuleman Philip
Center for Vaccinology, Dept. of Clinical Chemistry, Microbiology and Immunology, Ghent University, Ghent, Belgium; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA.
Division of Gastroenterology and Hepatology, Weill Cornell Medical College, New York, USA; Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, USA.
Curr Opin Virol. 2015 Aug;13:67-74. doi: 10.1016/j.coviro.2015.04.009. Epub 2015 May 23.
The development and evaluation of effective therapies and vaccines for the hepatitis C virus (HCV) and the study of its interactions with the mammalian host have been hindered for a long time by the absence of suitable small animal models. Immune compromised mouse models that recapitulate the complete HCV life cycle have been useful to investigate many aspects of the HCV life cycle including antiviral interventions. However, HCV has a high propensity to establish persistence and associated histopathological manifestations such as steatosis, fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Better understanding of these processes requires the development of a permissive and fully immunocompetent small animal model. In this review we summarize the in vivo models that are available for the study of HCV.
长期以来，由于缺乏合适的小动物模型，丙型肝炎病毒（HCV）有效治疗方法和疫苗的研发与评估以及其与哺乳动物宿主相互作用的研究一直受到阻碍。能够重现完整HCV生命周期的免疫受损小鼠模型，对于研究HCV生命周期的许多方面（包括抗病毒干预）很有用。然而，HCV具有很高的持续性倾向以及相关的组织病理学表现，如脂肪变性、纤维化、肝硬化和肝细胞癌（HCC）。要更好地理解这些过程，需要开发一种允许且具有完全免疫能力的小动物模型。在这篇综述中，我们总结了可用于研究HCV的体内模型。
