用于研究丙型肝炎和宿主相互作用的人源化小鼠模型。
Humanized Mouse Models for the Study of Hepatitis C and Host Interactions.
机构信息
Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore 138673, Singapore.
Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.
出版信息
Cells. 2019 Jun 17;8(6):604. doi: 10.3390/cells8060604.
Hepatitis C virus (HCV) infection is commonly attributed as a major cause of chronic hepatotropic diseases, such as, steatosis, cirrhosis and hepatocellular carcinoma. As HCV infects only humans and primates, its narrow host tropism hampers in vivo studies of HCV-mammalian host interactions and the development of effective therapeutics and vaccines. In this context, we will focus our discussion on humanized mice in HCV research. Here, these humanized mice are defined as animal models that encompass either only human hepatocytes or both human liver and immune cells. Aspects related to immunopathogenesis, anti-viral interventions, drug testing and perspectives of these models for future HCV research will be discussed.
丙型肝炎病毒（HCV）感染通常被认为是慢性嗜肝疾病的主要原因，如脂肪变性、肝硬化和肝细胞癌。由于 HCV 仅感染人类和灵长类动物，其宿主的局限性阻碍了 HCV 与哺乳动物宿主相互作用的体内研究以及有效治疗方法和疫苗的开发。在这种情况下，我们将重点讨论丙型肝炎病毒研究中的人源化小鼠。在这里，这些人源化小鼠被定义为仅包含人类肝细胞或同时包含人类肝脏和免疫细胞的动物模型。本文将讨论与免疫发病机制、抗病毒干预、药物测试以及这些模型对未来丙型肝炎病毒研究的展望相关的方面。
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