Giuliano Michael W, Miller Scott J
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT, 06520-8107, USA.
Top Curr Chem. 2016;372:157-201. doi: 10.1007/128_2015_653.
The problem of catalyst-controlled site-selectivity can potentially require a catalyst to overcome energetic barriers larger than those associated with enantioselective reactions. This challenge is a signature of substrates that present reactive sites that are not of equivalent reactivity. Herein we present a narrative of our laboratory's efforts to overcome this challenge using peptide-based catalysts. We highlight the interplay between understanding the inherent reactivity preferences of a given target molecule and the development of catalysts that can overcome intrinsic preferences embedded within a substrate.
催化剂控制的位点选择性问题可能需要催化剂克服比对映选择性反应相关的能垒更大的能垒。这一挑战是具有不等同反应活性的反应位点的底物的一个特征。在此，我们讲述了我们实验室使用基于肽的催化剂来克服这一挑战的努力。我们强调了理解给定目标分子的固有反应活性偏好与开发能够克服底物中固有偏好的催化剂之间的相互作用。
