Warner Freda M, Cragg Jacquelyn J, Weisskopf Marc G, Kramer John K
School of Kinesiology, University of British Columbia, Vancouver, BC, Canada; International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada.
International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver, BC, Canada; Harvard School of Public Health Neuroepidemiology Research Group, Boston, MA, United States of America.
PLoS One. 2015 Aug 26;10(8):e0135550. doi: 10.1371/journal.pone.0135550. eCollection 2015.
Migraine headaches are a common neurological condition, negatively impacting health and quality of life. The association between migraines and spinal cord injury (SCI) is intriguing to consider from the perspective that migraine headaches may be acquired in response to damage in the spinal cord [corrected].The primary objective of this study was to further examine the association between SCI and migraine headache, controlling for potential confounding variables. A secondary objective was to determine the impact of migraine headaches on self-perceived health. Data from a sample of 61,047 participants were obtained from the cross-sectional Canadian Community Health Survey. Multivariable logistic regression was used to explore the association between SCI and migraine headache using probability weights and adjusting for confounders. The multivariable age- and sex-adjusted model revealed a strong association between SCI and migraine headache, with an adjusted odds ratio for migraine of 4.82 (95% confidence interval [3.02, 7.67]) among those with SCI compared to those without SCI. Further, individuals who experienced both SCI and migraine tended to report poorer perceived general health compared with the other groups (i.e., SCI and no migraine). In conclusion, this study established a strong association between SCI and migraine headache. Further research is needed to explore the possible mechanisms underlying this relationship. Improvements in clinical practice to minimize this issue could result in significant improvements in quality of life.
偏头痛是一种常见的神经系统疾病，对健康和生活质量有负面影响。从偏头痛可能因脊髓损伤而引发的角度来看，偏头痛与脊髓损伤（SCI）之间的关联值得深入探讨[已修正]。本研究的主要目的是进一步研究脊髓损伤与偏头痛之间的关联，并控制潜在的混杂变量。次要目的是确定偏头痛对自我感知健康的影响。来自61047名参与者样本的数据取自加拿大社区健康调查的横断面数据。使用多变量逻辑回归，通过概率权重并对混杂因素进行调整，来探究脊髓损伤与偏头痛之间的关联。多变量年龄和性别调整模型显示，脊髓损伤与偏头痛之间存在强烈关联，与无脊髓损伤者相比，脊髓损伤者患偏头痛的调整优势比为4.82（95%置信区间[3.02, 7.67]）。此外，与其他组（即有脊髓损伤但无偏头痛者）相比，同时经历脊髓损伤和偏头痛的个体往往报告自我感知的总体健康状况较差。总之，本研究证实了脊髓损伤与偏头痛之间存在强烈关联。需要进一步研究来探索这种关系背后的可能机制。在临床实践中改善以尽量减少这个问题，可能会显著提高生活质量。
