From the School of Population and Public Health, Faculty of Medicine (J.J.C.), International Collaboration on Repair Discoveries (J.J.C., A.K., J.F.B.), Division of Spine, Department of Orthopaedics (M.D.), Department of Medicine, Division of Physical Medicine and Rehabilitation (A.K.), and Cardiovascular Imaging Research Core Laboratory, Division of Cardiology, Department of Medicine (G.B.J.M.), University of British Columbia, Vancouver; Rick Hansen Institute (V.K.N.), Vancouver; Acute Spine Program (M.D.), Vancouver General Hospital; GF Strong Rehabilitation Centre (A.K.), Vancouver Health Authority, Vancouver; and British Columbia Institute of Technology (J.F.B.), Burnaby, Canada.
Neurology. 2013 Nov 19;81(21):1864-8. doi: 10.1212/01.wnl.0000436074.98534.6e. Epub 2013 Oct 23.
The objective of this study was to evaluate the association between spinal cord injury (SCI) and type 2 diabetes in a large representative sample and to determine whether an association exists irrespective of known risk factors for type 2 diabetes.
Data were obtained on 60,678 respondents to the Statistics Canada 2010 Cycle of the cross-sectional Canadian Community Health Survey. Multivariable logistic regression, incorporating adjustment for confounders and probability weights to account for the Canadian Community Health Survey sampling method, was conducted to quantify this association.
After adjustment for both sex and age, SCI was associated with a significant increased odds of type 2 diabetes (adjusted odds ratio = 1.66, 95% confidence interval 1.16-2.36). These heightened odds persisted after additional adjustment for smoking status, hypertension status, body mass index, daily physical activity, alcohol intake, and daily consumption of fruits and vegetables (fully adjusted odds ratio = 2.45, 95% confidence interval 1.34-4.47).
There is a strong association between SCI and type 2 diabetes, which is not explained by known risk factors for type 2 diabetes.
本研究旨在评估在一个大的代表性样本中，脊髓损伤 (SCI) 与 2 型糖尿病之间的关联，并确定这种关联是否存在于 2 型糖尿病的已知危险因素之外。
本研究的数据来自于加拿大 2010 年全国健康调查（Canadian Community Health Survey）的横断面调查，共涉及 60678 名受访者。采用多变量逻辑回归分析，同时调整混杂因素和概率权重以考虑加拿大社区健康调查的抽样方法，对这种关联进行量化。
在调整了性别和年龄因素后，SCI 与 2 型糖尿病的发生显著相关，其比值比（odds ratio）为 1.66（95%置信区间为 1.16-2.36）。在进一步调整了吸烟状况、高血压状况、体重指数、日常体力活动、饮酒量以及每日水果和蔬菜摄入量等因素后，这种关联仍然存在（完全调整后的比值比为 2.45，95%置信区间为 1.34-4.47）。
SCI 与 2 型糖尿病之间存在强烈的关联，这种关联不能用 2 型糖尿病的已知危险因素来解释。
