Sulotto F, Romano C, Piolatto G, Chiesa A, Ciacco C
Med Lav. 1989 Nov-Dec;80(6):498-505.
Ten subjects with occupational asthma who, were either no longer exposed or had minimal exposure, were controlled every three months after cessation of exposure. All subjects showed airway responsiveness to metacholine, complained of mild symptoms and had minor lung function abnormalities. The subjects underwent inhalation therapy with beclomethasone dipropionate (2000 micrograms/day) for 3 to 12 months. Although pulmonary function values and symptoms did not change significantly during treatment, PD20 FEV1 improved markedly after 3 months and further improved after the longest period of treatment. PD20 FEV1 after treatment was significantly correlated with the base PD20 FEV1 value and not with the FEV1 increase. Good therapeutic results were obtained in 6 subjects. In the remaining 4 subjects who did not respond to treatment, the base PD20 FEV1 value was below 200 micrograms. In 4 of the 6 subjects who responded to treatment PD20 FEV1 was lower than during treatment but higher than before treatment.
10名职业性哮喘患者，要么不再接触致病因素，要么接触程度极低，在停止接触后每三个月接受一次检查。所有患者对乙酰甲胆碱均有气道反应性，主诉有轻微症状，且肺功能有轻微异常。这些患者接受了丙酸倍氯米松吸入治疗（2000微克/天），为期3至12个月。虽然治疗期间肺功能值和症状没有明显变化，但治疗3个月后PD20 FEV1显著改善，治疗最长时间后进一步改善。治疗后的PD20 FEV1与基础PD20 FEV1值显著相关，与FEV1增加无关。6名患者取得了良好的治疗效果。其余4名对治疗无反应的患者，基础PD20 FEV1值低于200微克。在6名对治疗有反应的患者中，有4名患者的PD20 FEV1低于治疗期间但高于治疗前。
