培美曲塞对经过大量预处理的转移性乳腺外佩吉特病产生了持久的疗效。
Pemetrexed induced a durable response in heavily pretreated metastatic extramammary Paget's disease.
作者信息
Wu Chao, Tao Hai-Tao, Li Fang-Fang, Huang Shang-Wu, Dong Wei-Wei, Wang Jin-Liang, Hu Yi, Li Fang
机构信息
Department of Oncology, Chinese PLA General Hospital 28 Fuxing Road, Haidian District, Beijing 100853, China.
Department of Health Academy, Chinese PLA General Hospital 28 Fuxing Road.
出版信息
Int J Clin Exp Med. 2015 Jun 15;8(6):9595-8. eCollection 2015.
PURPOSE
Extramammary Paget's disease (EMPD) is a rare neoplasm with only a limited number of cases reported in the literature. Little was known about the availability of systemic chemotherapy for metastatic EMPD.
METHODS
We report one case of heavily pretreated EMPD with multiple organ metastases and successfully treated by pemetrexed.
RESULT
The tumor was progression after multi-line therapy including erlotinib, radiotherapy, combined chemotherapy and radioactive particles implantation. Pemetrexed monotherapy was applied and progression free survival of more than 5 months with partial remission (PR) response was achieved. Only 1 time of grade 3 neutropenia was observed during the pemetrexed chemotherapy.
CONCLUSION
Due to the significant response and tolerability in the present case, pemetrexed monotherapy was recommended as a potent candidate for patients with advanced EMPD.
目的
乳腺外佩吉特病（EMPD）是一种罕见的肿瘤，文献中报道的病例数量有限。关于转移性EMPD全身化疗的可用性知之甚少。
方法
我们报告1例接受过大量治疗的EMPD伴多器官转移，经培美曲塞成功治疗。
结果
该肿瘤在接受包括厄洛替尼、放疗、联合化疗和放射性粒子植入在内的多线治疗后进展。应用培美曲塞单药治疗，实现了超过5个月的无进展生存期，部分缓解（PR）反应。在培美曲塞化疗期间仅观察到1次3级中性粒细胞减少。
结论
鉴于本病例中的显著反应和耐受性，培美曲塞单药治疗被推荐作为晚期EMPD患者的有效候选方案。
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