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老年人乳制品消费与衰弱风险:一项前瞻性队列研究。

Dairy Consumption and Risk of Frailty in Older Adults: A Prospective Cohort Study.

作者信息

Lana Alberto, Rodriguez-Artalejo Fernando, Lopez-Garcia Esther

机构信息

Department of Medicine, Preventive Medicine and Public Health Area, School of Medicine and Health Sciences, University of Oviedo, Oviedo, Spain.

Department of Preventive Medicine and Public Health, School of Medicine, Universidad Autónoma de Madrid, IdiPaz (Instituto de Investigación Sanitaria Hospital Universitario La Paz); and CIBERESP (CIBER of Epidemiology and Public Health), Madrid, Spain.

出版信息

J Am Geriatr Soc. 2015 Sep;63(9):1852-60. doi: 10.1111/jgs.13626. Epub 2015 Aug 27.

Abstract

OBJECTIVES

To examine the association between consumption of dairy products and risk of frailty in community-dwelling older adults.

DESIGN

Prospective cohort study.

SETTING

General population from the older cohort of the Study on Nutrition and Cardiovascular Risk in Spain.

PARTICIPANTS

Community-dwelling adults aged 60 and older free of frailty at baseline (N = 1,871).

MEASUREMENTS

From 2008 to 2010, food consumption was assessed using a validated diet history. Participants were examined again in 2012 to assess incident frailty, defined as at least three of the five Fried criteria (exhaustion, weakness, low physical activity, slow walking speed, unintentional weight loss). Adjusted odds ratios (OR) for the main confounders were obtained using logistic regression.

RESULTS

During follow-up, 134 new cases of frailty were identified. Participants consuming seven or more servings per week of low-fat milk and yogurt had lower incidence of frailty (OR = 0.52; 95% confidence interval (CI) = 0.29-0.90; P for trend = .03) than those consuming less than one serving per week. Specifically, consumers of seven or more servings per week of low-fat milk and yogurt had less risk of slow walking speed (OR = 0.64, 95% CI = 0.44-0.92, P trend = .01) and of weight loss (OR = 0.54, 95% CI = 0.33-0.87, P trend = .02). Consuming seven or more servings per week of whole milk or yogurt (OR = 1.53, 95% CI = 0.90-2.60, P trend = .10) or of cheese (OR = 0.91, 95% CI = 0.52-1.61; P trend = .61) was not associated with incident frailty.

CONCLUSION

Higher consumption of low-fat milk and yogurt was associated with lower risk of frailty and, specifically, of slow walking speed and weight loss. Current recommendations to prevent frailty include protein supplementation; thus, although experimental research is needed, increasing the consumption of low-fat yogurt and milk might prevent frailty in older adults.

摘要

目的

研究社区居住的老年人食用乳制品与虚弱风险之间的关联。

设计

前瞻性队列研究。

背景

来自西班牙营养与心血管风险研究老年队列的普通人群。

参与者

基线时无虚弱的60岁及以上社区居住成年人(N = 1871)。

测量

2008年至2010年,使用经过验证的饮食史评估食物摄入量。2012年再次对参与者进行检查,以评估新发虚弱情况,定义为符合五项Fried标准(疲惫、虚弱、身体活动少、步行速度慢、非故意体重减轻)中的至少三项。使用逻辑回归获得主要混杂因素的调整比值比(OR)。

结果

随访期间,确定了134例新的虚弱病例。每周食用七份或更多份低脂牛奶和酸奶的参与者,其虚弱发生率(OR = 0.52;95%置信区间(CI)= 0.29 - 0.90;趋势P值 = 0.03)低于每周食用少于一份的参与者。具体而言,每周食用七份或更多份低脂牛奶和酸奶的消费者,步行速度慢(OR = 0.64,95% CI = 0.44 - 0.92,趋势P值 = 0.01)和体重减轻(OR = 0.54,95% CI = 0.33 - 0.87,趋势P值 = 0.02)的风险较低。每周食用七份或更多份全脂牛奶或酸奶(OR = 1.53,95% CI = 0.90 - 2.60,趋势P值 = 0.10)或奶酪(OR = 0.91,95% CI = 0.52 - 1.61;趋势P值 = 0.61)与新发虚弱无关。

结论

较高的低脂牛奶和酸奶摄入量与较低的虚弱风险相关,特别是与步行速度慢和体重减轻风险相关。目前预防虚弱的建议包括补充蛋白质;因此,尽管需要进行实验研究,但增加低脂酸奶和牛奶的摄入量可能预防老年人虚弱。

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