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发酵乳制品、老年人的肌肉骨骼和心理健康:是否有证据支持其益处超越非发酵乳制品?

Fermented Dairy Products, Musculoskeletal and Mental Health in Older Adults: is There Evidence to Support Benefits that go Beyond Those of Non-Fermented Dairy Products?

机构信息

Division of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, University of Geneva, 1205, Geneva, Switzerland.

Department of Nutrition and Dietetics, Harokopio University, 17671, Athens, Greece.

出版信息

Calcif Tissue Int. 2024 Nov;115(5):480-497. doi: 10.1007/s00223-024-01291-4. Epub 2024 Sep 20.

DOI:10.1007/s00223-024-01291-4
PMID:39302464
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11531444/
Abstract

Fermented dairy products have recently gained popularity due to their purported health benefits, nevertheless, their role in ageing remains uncertain. This narrative review aims to evaluate evidence from observational (prospective) and interventional studies on the potential benefits of fermented dairy product consumption for musculoskeletal and mental health in older adults. Additionally, it seeks to determine whether any observed benefits surpass those of non-fermented dairy products and to identify directions for future research. Prospective studies support either favourable or neutral associations of fermented dairy products with outcomes of musculoskeletal health or neutral associations with mental health outcomes, whilst it remains unclear if the benefits observed with fermented dairy products go beyond those of the non-fermented dairy foods. Few interventional studies suggest overall favourable effects of yogurt and cheese on musculoskeletal health in older adults but given their small number (N = 6) and heterogeneity, they do not allow a clear assessment or definitive recommendations for fermented dairy intake. Interventional studies reporting mental health outcomes are largely lacking for this age group (N = 1). Given the very limited evidence for the effectiveness of fermented dairy products, future well-designed prospective and randomized controlled trials are needed to better understand their benefits (especially compared to those of non-fermented dairy foods), their characteristics and the quantities required to offer protection against musculoskeletal and/or mental health ageing.

摘要

发酵乳制品因其据称的健康益处最近受到关注,但它们在衰老过程中的作用仍不确定。本综述旨在评估观察性(前瞻性)和干预性研究中关于发酵乳制品消费对老年人肌肉骨骼和心理健康潜在益处的证据。此外,还试图确定观察到的益处是否超过非发酵乳制品,并确定未来研究的方向。前瞻性研究支持发酵乳制品与肌肉骨骼健康结果之间存在有利或中性的关联,或与心理健康结果之间存在中性关联,而发酵乳制品的益处是否超过非发酵乳制品仍不清楚。少数干预研究表明酸奶和奶酪对老年人肌肉骨骼健康有整体有利的影响,但由于数量较少(N=6)且存在异质性,因此无法对发酵乳制品摄入进行明确评估或做出明确建议。针对该年龄组的报告心理健康结果的干预研究很少(N=1)。鉴于发酵乳制品有效性的证据非常有限,需要进行精心设计的前瞻性和随机对照试验,以更好地了解它们的益处(尤其是与非发酵乳制品相比)、它们的特点以及提供对肌肉骨骼和/或心理健康衰老的保护所需的数量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b3/11531444/761999e4e7ce/223_2024_1291_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b3/11531444/761999e4e7ce/223_2024_1291_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a3b3/11531444/761999e4e7ce/223_2024_1291_Fig1_HTML.jpg

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Nonfermented Dairy Intake, but Not Fermented Dairy Intake, Associated with a Higher Risk of Depression in Middle-Age and Older Finnish Men.非发酵乳制品摄入与中年及以上芬兰男性抑郁风险增加相关,而发酵乳制品摄入则不然。
J Nutr. 2022 Aug 9;152(8):1916-1926. doi: 10.1093/jn/nxac128.
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