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引起真菌血症的解脂耶氏酵母（念珠菌属）分离株的临床特征、实验室鉴定及体外抗真菌药敏性：一项多中心前瞻性监测研究

Clinical Characteristics, Laboratory Identification, and In Vitro Antifungal Susceptibility of Yarrowia (Candida) lipolytica Isolates Causing Fungemia: a Multicenter, Prospective Surveillance Study.

作者信息

Zhao Ying, Chan Jasper Fuk-Woo, Tsang Chi-Ching, Wang He, Guo Dawen, Pan Yuhong, Xiao Yuling, Yue Na, Chen Jonathan Hon-Kwan, Lau Susanna Kar-Pui, Xu Yingchun, Woo Patrick Chiu-Yat

机构信息

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.

State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Department of Microbiology, The University of Hong Kong, Hong Kong Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Carol Yu Centre for Infection, The University of Hong Kong, Hong Kong.

出版信息

J Clin Microbiol. 2015 Nov;53(11):3639-45. doi: 10.1128/JCM.01985-15. Epub 2015 Aug 26.

DOI:10.1128/JCM.01985-15
PMID:26311865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4609733/
Abstract

Our case series showed that uncomplicated Yarrowia lipolytica fungemia might be treated with catheter removal alone. The Vitek 2 YST identification (ID) card system, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), and internal transcribed spacer and 25S nuclear ribosomal DNA (nrDNA) gene sequencing provided reliable identification. All isolates had low MICs to voriconazole, echinocandins, and amphotericin B.

摘要

我们的病例系列表明，单纯拔除导管可能就可以治疗无并发症的解脂耶氏酵母菌血症。Vitek 2 YST鉴定（ID）卡系统、基质辅助激光解吸电离飞行时间质谱（MALDI-TOF MS）以及内转录间隔区和25S核糖体DNA（nrDNA）基因测序提供了可靠的鉴定结果。所有分离株对伏立康唑、棘白菌素和两性霉素B的最低抑菌浓度都很低。

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