Mycology Unit, Microbiology Division, Department of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar
Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar Weill-Cornel Medical College, Qatar.
Med Mycol. 2014 Jul;52(5):552-6. doi: 10.1093/mmycol/myu016. Epub 2014 Jun 15.
Eleven uncommon yeast species that are associated with high mortality rates irrespective of antifungal therapy were isolated from 17/187 (201 episodes) pediatric and elderly patients with fungemia from Qatar. The samples were taken over a 6-year period (January 2004-December 2010). Isolated species included Kluyveromyces marxianus, Lodderomyces elongisporus, Lindnera fabianii, Candida dubliniensis, Meyerozyma guilliermondii, Candida intermedia, Pichia kudriavzevii, Yarrowia lipolytica, Clavispora lusitaniae, Candida pararugosa, and Wickerhamomyces anomalus. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry provided correct identifications compared with molecular analysis testing of the same isolates. Low minimal inhibitory concentrations were found when isavuconazole and voriconazole were used for all uncommon yeast species evaluated in this study. Resistance to antifungal drugs was low and remained restricted to a few species.
从卡塔尔的 17/187 名（201 例）患有真菌血症的儿科和老年患者中分离出 11 种不常见的酵母物种，这些物种与抗真菌治疗无关，死亡率很高。这些样本是在 6 年期间（2004 年 1 月至 2010 年 12 月）采集的。分离出的物种包括马克斯克鲁维酵母、 elongisporus 毕赤酵母、fabianii 蔺草假丝酵母、都柏林假丝酵母、guilliermondii 迈耶罗酵母、中间假丝酵母、毕赤酵母、lipolytica 解脂耶氏酵母、lusitaniae 克鲁维酵母、pararugosa 假丝酵母和anomalus 异常威克汉姆酵母。与对相同分离株进行的分子分析测试相比，基质辅助激光解吸/电离飞行时间质谱提供了正确的鉴定。当使用伊曲康唑和伏立康唑评估本研究中评估的所有不常见酵母物种时，发现最低抑菌浓度较低。抗真菌药物的耐药性较低，仅限于少数几种。
