传染性法氏囊病病毒VP3上调VP1介导的RNA依赖性RNA复制。
Infectious Bursal Disease Virus VP3 Upregulates VP1-Mediated RNA-Dependent RNA Replication.
作者信息
Ferrero Diego, Garriga Damià, Navarro Aitor, Rodríguez José F, Verdaguer Núria
机构信息
Centro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain.
Centro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain.
出版信息
J Virol. 2015 Nov;89(21):11165-8. doi: 10.1128/JVI.00218-15. Epub 2015 Aug 26.
Abstract
Genome replication is a critical step in virus life cycles. Here, we analyzed the role of the infectious bursal disease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein complexes, on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp). Data show that VP3, as well as a peptide mimicking its C-terminal domain, efficiently stimulates the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3' untranslated regions (UTRs) from the IBDV genome segments.
摘要
基因组复制是病毒生命周期中的关键步骤。在此，我们分析了传染性法氏囊病病毒（IBDV）的VP3（IBDV核糖核蛋白复合物的主要成分）对病毒编码的RNA依赖性RNA聚合酶（RdRp）VP1的调控作用。数据表明，VP3以及模拟其C末端结构域的肽，能有效刺激VP1复制包含IBDV基因组片段3'非翻译区（UTR）的合成单链RNA模板的能力。
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