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一例酷似皮肤垢着病的泛发性蛎壳状银屑病。

A case of generalized ostraceous psoriasis mimicking dermatitis neglecta.

作者信息

Nascimento Bianca Angelina Macêdo do, Carvalho Alessandra Haber, Dias Carolina Moraes, Lage Thaiane Lima, Carneiro Clívia Maria Oliveira, Bittencourt Maraya de Jesus Semblano

机构信息

Universidade Federal do Pará, Belém, PA, BR.

Brazil, BR.

出版信息

An Bras Dermatol. 2015 May-Jun;90(3 Suppl 1):197-9. doi: 10.1590/abd1806-4841.20153858.

DOI:10.1590/abd1806-4841.20153858
PMID:26312715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4540549/
Abstract

Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis (and its resistance to treatment) is one of the major reasons for noncompliance in patients treated with lithium. We describe a male patient who developed generalized ostraceous psoriasis whose clinical appearance mimicked dermatitis neglecta, 10 months after starting therapy with lithium.

摘要

锂已被认为与原有银屑病的加重、在银屑病患者先前未受累皮肤诱发银屑病以及在无个人或家族病史的患者中首次引发银屑病有关。锂诱导的银屑病(及其对治疗的抵抗性)是锂治疗患者不依从的主要原因之一。我们描述了一名男性患者,在开始锂治疗10个月后出现了全身性蛎壳状银屑病,其临床表现类似忽视性皮炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af8/4540549/4c008460dc01/abd-90-03-s1-0197-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af8/4540549/94447dbc616d/abd-90-03-s1-0197-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af8/4540549/4c008460dc01/abd-90-03-s1-0197-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af8/4540549/94447dbc616d/abd-90-03-s1-0197-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7af8/4540549/4c008460dc01/abd-90-03-s1-0197-g02.jpg

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本文引用的文献

1
Lithium regulates keratinocyte proliferation via glycogen synthase kinase 3 and NFAT2 (nuclear factor of activated T cells 2).锂通过糖原合酶激酶 3 和 NFAT2(激活的 T 细胞核因子 2)调节角质形成细胞增殖。
J Cell Physiol. 2012 Apr;227(4):1529-37. doi: 10.1002/jcp.22872.
2
Drug induced psoriasis.药物性银屑病
Acta Dermatovenerol Croat. 2011;19(1):39-42.
3
The role of drugs in the induction and/or exacerbation of psoriasis.药物在诱导和/或加重银屑病中的作用。
Int J Dermatol. 2010 Dec;49(12):1351-61. doi: 10.1111/j.1365-4632.2010.04570.x.
4
A case of generalized dermatitis neglecta mimicking psoriasis vulgaris.1例酷似寻常型银屑病的广泛性忽视性皮炎。
Arch Dermatol. 2010 Sep;146(9):1050-1. doi: 10.1001/archdermatol.2010.228.
5
Dermatosis neglecta: a report of two cases.
An Bras Dermatol. 2010 Mar-Apr;85(2):217-20. doi: 10.1590/s0365-05962010000200012.
6
Lithium and skin: dermatologic manifestations of lithium therapy.锂与皮肤:锂治疗的皮肤表现
Int J Dermatol. 2008 Nov;47(11):1101-11. doi: 10.1111/j.1365-4632.2008.03873.x.
7
Evidence that the immunopathogenic mechanism of lithium-induced psoriasis differs from that of regular psoriasis.
Bipolar Disord. 2005 Aug;7(4):388-9. doi: 10.1111/j.1399-5618.2005.00214.x.