Silva Danieli Cristina da, Lourenço Alan Grupioni, Ribeiro Ana Elisa Rodrigues Alves, Machado Alcyone Artioli, Komesu Marilena Chinali, Motta Ana Carolina Fragoso
Department of Stomatology, Public Oral Health and Forensic Dentistry, School of Dentistry of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
Department of Internal Medicine, School of Medicine of Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, BR.
Braz Oral Res. 2015;29:1-6. doi: 10.1590/1807-3107BOR-2015.vol29.0101. Epub 2015 Aug 21.
Considering the changes antiretroviral therapy (ART) has brought to the treatment of HIV infection, the current clinical and laboratory profiles of HIV/AIDS individuals referred to oral health centers are crucially important in instructing dentists about the oral health management of these patients. The aim of the present study was to determine the clinical and laboratory profiles of HIV-infected individuals referred to a clinic for patients with special needs between 2005 and 2012 by retrospectively analyzing their dental records. A total of 97 records of HIV patients referred to the School of Dentistry of Ribeirão Preto, Universidade de São Paulo - USP, were analyzed. The Mann-Whitney test was used to determine the associations between mean CD4+ counts, mean viral load, and the presence of HIV-related oral lesions (HIV-OL). Most of the patients were male, and their mean age was 38.3 years. Eighty-nine (92%) patients were on regular ART, 77 (79.4%) had a CD4+ count higher than 200 cells/mm3, and 63 (64.9%) had an undetectable viral load. Twenty patients (20.6%) presented with some HIV-OL, including pseudomembranous and/or erythematous candidiasis and angular cheilitis, which were correlated with a low CD4+ count and with an undetectable viral load (p < 0.05). Among the branches of dentistry, periodontics, followed by surgery and restorative dentistry, was the most sought-after specialty, and no intercurrent events were observed during the dental treatment. It may be concluded that there are no restrictions on the dental treatment of patients on regular ART, It is important, though, that the treatment be based on local characteristics and on the prevention of oral diseases.
考虑到抗逆转录病毒疗法(ART)给HIV感染治疗带来的变化,前往口腔健康中心就诊的HIV/AIDS患者当前的临床和实验室特征对于指导牙医对这些患者进行口腔健康管理至关重要。本研究的目的是通过回顾性分析2005年至2012年间前往一所特殊需求患者诊所就诊的HIV感染者的牙科记录,来确定其临床和实验室特征。对总共97份转诊至圣保罗大学皮拉西卡巴牙科学院(USP)的HIV患者记录进行了分析。采用Mann-Whitney检验来确定平均CD4 +细胞计数、平均病毒载量与HIV相关口腔病变(HIV-OL)之间的关联。大多数患者为男性,平均年龄为38.3岁。89名(92%)患者正在接受常规ART治疗,77名(79.4%)患者的CD4 +细胞计数高于200个/立方毫米,63名(64.9%)患者的病毒载量检测不到。20名(20.6%)患者出现了一些HIV-OL,包括假膜性和/或红斑性念珠菌病以及口角炎,这些与低CD4 +细胞计数和病毒载量检测不到相关(p < 0.05)。在牙科各分支中,牙周病学,其次是外科和修复牙科,是最受欢迎的专业,并且在牙科治疗期间未观察到并发事件。可以得出结论,接受常规ART治疗的患者在牙科治疗方面没有限制,不过,重要的是治疗应基于当地情况和口腔疾病的预防。