远程缺血后处理对经历缺血再灌注的大鼠肺实质炎症变化的影响。
Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion.
作者信息
Dorsa Rafael Cantero, Pontes José Carlos Dorsa Vieira, Antoniolli Andréia Conceição Brochado, Silva Guilherme Viotto Rodrigues da, Benfatti Ricardo Adala, Santos Carlos Henrique Marques dos, Pontes Elenir Rose Cury, Goldiano José Anderson Souza
机构信息
Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.
Nucleus of the University Hospital, Federal University of Mato Grosso do Sul, Campo Grande, MS, BR.
出版信息
Rev Bras Cir Cardiovasc. 2015 Jul-Sep;30(3):353-9. doi: 10.5935/1678-9741.20150005.
OBJECTIVE
To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.
METHODS
Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.
RESULTS
GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).
CONCLUSION
The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.
目的
评估远程后适应对大鼠肺缺血再灌注损伤的影响。
方法
将24只Wistar大鼠分为3组：GA（缺血/再灌注组）n = 8，GB（远程后适应组）n = 8，CG（对照组）n = 8，通过阻断腹主动脉30分钟造成缺血，随后再灌注60分钟。切除肺组织并根据组织损伤程度进行组织学分析和形态学结果分类。对组织损伤程度的平均评分进行统计分析。
结果
GA组（3.6分）、GB组（1.3分）和CG组（1.0分）。（GA与GB相比P<0.05）。
结论
远程后适应能够使经历缺血再灌注过程的大鼠肺实质的炎性损伤最小化。
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