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本文引用的文献

1
Targeting the Ataxia Telangiectasia Mutated-null phenotype in chronic lymphocytic leukemia with pro-oxidants.利用促氧化剂靶向慢性淋巴细胞白血病中共济失调毛细血管扩张突变缺失表型。
Haematologica. 2015 Aug;100(8):1076-85. doi: 10.3324/haematol.2014.115170. Epub 2015 Apr 3.
2
Three-year follow-up of treatment-naïve and previously treated patients with CLL and SLL receiving single-agent ibrutinib.初治和既往接受过治疗的慢性淋巴细胞白血病（CLL）和小淋巴细胞淋巴瘤（SLL）患者接受单药伊布替尼治疗的三年随访
Blood. 2015 Apr 16;125(16):2497-506. doi: 10.1182/blood-2014-10-606038. Epub 2015 Feb 19.
3
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?线粒体 ROS 在癌症中的作用：启动子、放大器还是致命弱点？
Nat Rev Cancer. 2014 Nov;14(11):709-21. doi: 10.1038/nrc3803.
4
Modulation of oxidative stress as an anticancer strategy.氧化应激调节作为一种抗癌策略。
Nat Rev Drug Discov. 2013 Dec;12(12):931-47. doi: 10.1038/nrd4002.
5
ATM mutations uniformly lead to ATM dysfunction in chronic lymphocytic leukemia: application of functional test using doxorubicin.ATM 突变普遍导致慢性淋巴细胞白血病中的 ATM 功能障碍：应用多柔比星进行功能测试。
Haematologica. 2013 Jul;98(7):1124-31. doi: 10.3324/haematol.2012.081620. Epub 2013 Apr 12.
6
Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions.共济失调毛细血管扩张症的发病机制：ATM 功能的下一代。
Blood. 2013 May 16;121(20):4036-45. doi: 10.1182/blood-2012-09-456897. Epub 2013 Feb 25.
7
Biallelic ATM inactivation significantly reduces survival in patients treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 trial.英国白血病研究基金慢性淋巴细胞白血病 4 期临床试验中，双等位基因 ATM 失活显著降低了患者的生存率。
J Clin Oncol. 2012 Dec 20;30(36):4524-32. doi: 10.1200/JCO.2011.41.0852. Epub 2012 Oct 22.
8
Monitoring chronic lymphocytic leukemia progression by whole genome sequencing reveals heterogeneous clonal evolution patterns.通过全基因组测序监测慢性淋巴细胞白血病的进展揭示了异质性的克隆进化模式。
Blood. 2012 Nov 15;120(20):4191-6. doi: 10.1182/blood-2012-05-433540. Epub 2012 Aug 22.
9
ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.ATM 基因突变在慢性淋巴细胞白血病患者中诱导独特的基因表达谱，并可预测疾病进展。
Haematologica. 2012 Jan;97(1):47-55. doi: 10.3324/haematol.2011.049270. Epub 2011 Oct 11.
10
Extreme telomere erosion in ATM-mutated and 11q-deleted CLL patients is independent of disease stage.ATM基因发生突变以及11号染色体长臂缺失的慢性淋巴细胞白血病（CLL）患者的端粒严重缩短与疾病分期无关。
Leukemia. 2012 Apr;26(4):826-30. doi: 10.1038/leu.2011.281. Epub 2011 Oct 11.

Oxidative stress as a therapeutic perspective for ATM-deficient chronic lymphocytic leukemia patients.

作者信息

Navrkalova Veronika, Kafkova Leona Raskova, Divoky Vladimir, Pospisilova Sarka

机构信息

CEITEC - Center of Molecular Medicine, Masaryk University, Brno and Department of Internal Medicine - Hematology and Oncology, University Hospital Brno.

Department of Biology, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.

出版信息

Haematologica. 2015 Aug;100(8):994-6. doi: 10.3324/haematol.2015.130260.

DOI:10.3324/haematol.2015.130260
PMID:26314081
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5004413/
Abstract
摘要