抗Ro/SSA结缔组织病患者中白细胞介素-1β水平升高与校正QTc间期延长有关。

Elevated IL-1β levels in anti-Ro/SSA connective tissue diseases patients with prolonged corrected QTc interval.

作者信息

Pisoni Cecilia N, Reina Silvia, Arakaki Diego, Eimon Alicia, Carrizo Carolina, Borda Enri

机构信息

Rheumatology and Immunology Section, Department of Internal Medicine, CEMIC, University of Buenos Aires, Argentina.

Pharmacology Unit, Dentistry School, University of Buenos Aires, and National Research Council of Argentina (CONICET), Buenos Aires, Argentina.

出版信息

Clin Exp Rheumatol. 2015 Sep-Oct;33(5):715-20. Epub 2015 Aug 27.

PMID:26314292

Abstract

OBJECTIVES

Patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) have increased IL-1β levels. IL-1β and other pro-inflammatory cytokines have a modulating activity on cardiac ion channels and have been associated with increased arrhythmic risk in rheumatoid arthritis patients. Likewise, adult patients with connective tissue diseases (CTDs) may have prolonged QTc intervals associated with the presence of anti-Ro/SSA antibodies. Our objective was to evaluate the presence of serum IL-1β in subjects with CTDs, in relation to the presence of anti-Ro/SSA antibodies and QTc interval duration.

METHODS

12-lead electrocardiograms (ECG) were performed and blood was withdrawn, measuring electrolytes, IL-1β anti-Ro/SSA antibodies by ELISA in 73 patients with CTDs.

RESULTS

55 patients were anti-Ro/SSA positive and 18 were anti-Ro/SSA negative. Patients with anti-Ro/SSA positive antibodies had a significantly greater median IL-1β serum level: 7.29 (range: 0.17-17.3 pg/ml) compared to patients with anti-Ro/SSA negative antibodies whose median was: 1.67 (range 0.55-4.12 pg/ml) p<0.001. The mean QTc interval values obtained in both groups were not significantly different (417.7±23.1 vs. 414.7±21.2, p=0.63). The QTc interval was prolonged in 11 (20%) patients, who were all anti-Ro/SSA positive versus 0 (0 %) in anti-Ro/SSA negative patients p=0.05. Median IL-1β levels were: 8.7 (range: 2.69-15.1 pg/ml) in patients with prolonged QTc interval versus median: 5.0 (range: 0.17-17.3 pg/ml) in those with normal QTc interval values (<440ms) p=0.006.

CONCLUSIONS

IL-1β is elevated in patients with CTDs that have both anti-Ro/SSA antibodies and prolonged QTc intervals.

摘要

目的

系统性红斑狼疮（SLE）和原发性干燥综合征（pSS）患者的白细胞介素-1β（IL-1β）水平升高。IL-1β和其他促炎细胞因子对心脏离子通道具有调节活性，并与类风湿关节炎患者心律失常风险增加有关。同样，结缔组织病（CTD）成年患者可能存在与抗Ro/SSA抗体相关的QTc间期延长。我们的目的是评估CTD患者血清IL-1β的存在情况，及其与抗Ro/SSA抗体和QTc间期持续时间的关系。

方法

对73例CTD患者进行12导联心电图（ECG）检查并采血，通过酶联免疫吸附测定法（ELISA）检测电解质、IL-1β及抗Ro/SSA抗体。

结果

55例患者抗Ro/SSA抗体阳性，18例抗Ro/SSA抗体阴性。抗Ro/SSA抗体阳性患者的血清IL-1β中位数水平显著更高：7.29（范围：0.17 - 17.3 pg/ml），而抗Ro/SSA抗体阴性患者的中位数为：1.67（范围0.55 - 4.12 pg/ml），p<0.001。两组获得的平均QTc间期值无显著差异（417.7±23.1对414.7±21.2，p = 0.63）。11例（20%）患者QTc间期延长，这些患者均为抗Ro/SSA抗体阳性，而抗Ro/SSA抗体阴性患者中QTc间期延长的比例为0（0%），p = 0.05。QTc间期延长患者的IL-1β中位数水平为：8.7（范围：2.69 - 15.1 pg/ml），而QTc间期正常（<440ms）患者的中位数为：5.0（范围：0.17 - 17.3 pg/ml），p = 0.006。