Tejerina Amparo Navea, Vujosevic Stela, Varano Monica, Egan Catherine, Sivaprasad Sobha, Menon Geeta, Massin Pascale, Verbraak Frank D, Lund-Andersen Henrik, Martinez Jose P, Jurgens Ignasi, Smets Erica, Coriat Caroline, Wiedemann Peter, Ágoas Vitor, Querques Giuseppe, Holz Frank G, Nunes Sandrina, Alves Dalila, Neves Catarina, Santos Torcato, Ribeiro Luisa, Bandello Francesco, Cunha-Vaz José
Fundacix00F3;n para el Fomento de la Investigacix00F3;n Sanitaria y Biomx00E9;dica (FISABIO-Oftalmologx00ED;a), Valencia, Spain.
Ophthalmic Res. 2015;54(3):118-23. doi: 10.1159/000438793. Epub 2015 Aug 21.
To characterize the 1-year progression of retinal thickness (RT) increase occurring in eyes with subclinical macular edema in type 2 diabetes.
Forty-eight type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (NPDR; levels 20 and 35 in the Early Treatment Diabetic Retinopathy Study) classified as presenting subclinical macular edema at baseline completed the 1-year follow-up period, from a sample of 194 followed in a 12-month observational and prospective study (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation of the retinal layers in these eyes was performed, followed by verification and correction by a human grader.
The highest increase in RT over the 1-year follow-up period for the 48 eyes/patients with subclinical macular edema was found in the inner nuclear layer (INL). Progression to clinical macular edema was also associated with increased thickening of other retinal layers aside from the INL. The microvascular disease activity shown by microaneurysm (MA) turnover ≥6 was associated with progression from subclinical to clinical macular edema.
Increases in RT occurring over a period of 1 year in diabetic eyes with mild NPDR and subclinical macular edema occur mainly in the INL. The development of clinical macular edema appears to be associated with increased thickening of other retinal layers and microvascular disease activity.
描述2型糖尿病患者亚临床黄斑水肿眼视网膜厚度（RT）增加的1年进展情况。
在一项为期12个月的观察性前瞻性研究（ClinicalTrials.gov标识符：NCT01145599）中，从194例受试者样本中选取了48例2型糖尿病患者的眼睛，这些患者患有轻度非增殖性糖尿病视网膜病变（NPDR；早期糖尿病视网膜病变研究中的20级和35级），基线时被分类为存在亚临床黄斑水肿，完成了1年的随访。对这些眼睛的视网膜层进行自动分割，随后由人工分级员进行验证和校正。
在48例患有亚临床黄斑水肿的眼睛/患者中，1年随访期内RT增加最多的是内核层（INL）。进展为临床黄斑水肿还与INL以外的其他视网膜层增厚增加有关。微动脉瘤（MA）周转率≥6所显示的微血管疾病活动与从亚临床黄斑水肿进展为临床黄斑水肿有关。
轻度NPDR和亚临床黄斑水肿的糖尿病眼中，1年内发生的RT增加主要发生在内核层。临床黄斑水肿的发生似乎与其他视网膜层增厚增加和微血管疾病活动有关。
