Yang Yang, Wang Anhe, Jia Yi, Brezesinski Gerald, Dai Luru, Zhao Jie, Li Junbai
National Center for Nanoscience and Technology, No. 11, Bei Yi Tiao Institution Beijing, 100190 (China), Fax: (+86) 10-82612629.
Chem Asian J. 2014 Aug;9(8):2126-31. doi: 10.1002/asia.201402141. Epub 2014 Jun 4.
Peptide p160-conjugated mesoporous silica nanoparticles (MSN) were fabricated and loaded with photosensitizer hypocrellin B (HB). The results indicate that the nanocomposites have better selectivity for cancer cells and higher cytotoxicity in photodynamic therapy in vitro. The nanocomposites can be used as a novel candidate in photodynamic therapy. This may be a general and promising method to modify nanoparticles to improve their cell affinity.
制备了肽p160偶联的介孔二氧化硅纳米颗粒（MSN）并负载了光敏剂竹红菌素 B（HB）。结果表明，该纳米复合材料在体外光动力疗法中对癌细胞具有更好的选择性和更高的细胞毒性。该纳米复合材料可作为光动力疗法中的一种新型候选物。这可能是一种通用且有前景的修饰纳米颗粒以提高其细胞亲和力的方法。
