Shi Quan, Yang Shuo, Jia Fangfang, Xu Juan
Department of Stomatology, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, 100853, Beijing, China.
Head Face Med. 2015 Aug 28;11:28. doi: 10.1186/s13005-015-0085-6.
Pain caused by orthodontic treatment can affect patient's compliance and even force them to terminate treatments. The aim of this meta-analysis is to evaluate of the analgesic effect of low level laser therapy (LLLT) after placement of the orthodontic separators.
Five databases: PubMed, Embase, Cochrane library, China Biology Medicine disc (SinoMed CBM), China National Knowledge Infrastructure (CNKI) were searched for all the appropriate studies in June, 2014. Two reviewers screened the research results under our inclusion criteria and evaluated the risk of bias independently. Then the data of the included studies was extracted for quantitative analysis by the Review Manager 5.1 software.
Six studies were included in our meta-analysis finally. Comparing to the placebo group, the LLLT has good analgesic effect at 6 h, 1d, 2d, 3d after placement of separators which is of statistical significance. While at 2 h, 4d, 5d after the placement, the results tend to support LLLT, but not statistically significant.
Based on current included studies, LLLT can reduce the pain caused by the placement of separators effectively. However, because of the high heterogeneity, well designed RCTs are required in the future.
正畸治疗引起的疼痛会影响患者的依从性，甚至迫使他们终止治疗。本荟萃分析的目的是评估正畸分离器放置后低强度激光治疗（LLLT）的镇痛效果。
2014年6月，检索了五个数据库：PubMed、Embase、Cochrane图书馆、中国生物医学光盘数据库（SinoMed CBM）、中国知网（CNKI），以查找所有合适的研究。两名评审员根据纳入标准筛选研究结果，并独立评估偏倚风险。然后，使用Review Manager 5.1软件提取纳入研究的数据进行定量分析。
最终有六项研究纳入我们的荟萃分析。与安慰剂组相比，LLLT在放置分离器后6小时、1天、2天、3天具有良好的镇痛效果，具有统计学意义。而在放置后2小时、4天、5天，结果倾向于支持LLLT，但无统计学意义。
基于目前纳入的研究，LLLT可以有效减轻分离器放置引起的疼痛。然而，由于异质性较高，未来需要设计良好的随机对照试验。
