更年期激素疗法对乳腺癌的影响：规避风险
The Effect of Menopausal Hormone Therapies on Breast Cancer: Avoiding the Risk.
作者信息
Flores Valerie A, Taylor Hugh S
机构信息
Women and Infants Hospital, Warren Alpert Medical School of Brown University, 222 Richmond Street, Providence, RI 02903, USA.
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA.
出版信息
Endocrinol Metab Clin North Am. 2015 Sep;44(3):587-602. doi: 10.1016/j.ecl.2015.05.007. Epub 2015 Jun 23.
Abstract
Estrogen and P treatment results in greater risk of breast cancer than placebo. Treatment with estrogen alone does not increase the risk of breast cancer, may be used by women who have had a hysterectomy, and may even result in a decreased risk of breast cancer. Continued research seeks to improve the understanding of the interplay between estrogen and progestogens that predispose to adverse effects on breast tissue. Caution over this hypothesized benefit is warranted until it is substantiated by data on the incidence of breast cancer in tissue selective estrogen complex users.
摘要
雌激素和孕激素联合治疗导致患乳腺癌的风险高于安慰剂。单独使用雌激素不会增加患乳腺癌的风险，已行子宫切除术的女性可以使用，甚至可能降低患乳腺癌的风险。持续的研究旨在增进对雌激素和孕激素之间相互作用的理解，这种相互作用会对乳腺组织产生不良影响。在组织选择性雌激素复合物使用者的乳腺癌发病率数据得到证实之前，对这种假设的益处保持谨慎是有必要的。
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