美国非鼻咽部头颈部淋巴上皮瘤样癌：一项基于人群的研究。
Non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma in the United States: A population-based study.
作者信息
Chan Jason Y K, Wong Eddy W Y, Ng Siu-Kwan, Vlantis Alexander C
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR.
出版信息
Head Neck. 2016 Apr;38 Suppl 1:E1294-300. doi: 10.1002/hed.24215. Epub 2015 Aug 28.
BACKGROUND
Non-nasopharyngeal head and neck lymphoepithelioma-like carcinoma (LELC) is a rate entity. The purpose of this study was to analyze its demographic, clinicopathologic, and survival characteristics.
METHODS
A cohort from the Surveillance, Epidemiology, and End Results (SEER) database of cases with non-nasopharyngeal head and neck LELC between 1973 and 2011.
RESULTS
There were 378 cases with 5-year overall survival (OS) of 70.5% and disease-specific survival (DSS) of 77.7%. The majority of cases were <60-year-old white men. Salivary gland LELC had the highest OS (80.8%) and DSS (85.7%) at 5 years. Multivariate analysis showed that older age, no surgery, and no radiation were independently significantly associated with worse survival (p < .05).
CONCLUSION
Non-nasopharyngeal head and neck LELC is uncommon in the United States with salivary gland LELC having the highest OS and DSS compared with other head and neck sites. The optimal treatment with surgery and/or radiotherapy needs to be further investigated. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1294-E1300, 2016.
背景
非鼻咽部头颈部淋巴上皮瘤样癌（LELC）是一种罕见的实体瘤。本研究的目的是分析其人口统计学、临床病理及生存特征。
方法
对监测、流行病学和最终结果（SEER）数据库中1973年至2011年间非鼻咽部头颈部LELC病例组成的队列进行研究。
结果
共378例，5年总生存率（OS）为70.5%，疾病特异性生存率（DSS）为77.7%。大多数病例为60岁以下的白人男性。唾液腺LELC的5年OS（80.8%）和DSS（85.7%）最高。多因素分析显示，年龄较大、未行手术及未接受放疗与较差的生存率独立显著相关（p < 0.05）。
结论
非鼻咽部头颈部LELC在美国并不常见，与其他头颈部部位相比，唾液腺LELC的OS和DSS最高。手术和/或放疗的最佳治疗方案有待进一步研究。© 2015威利期刊公司。《头颈》38: E1294 - E1300, 2016。
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