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健康老年人移位型股骨颈骨折的双极半髋关节置换术与全髋关节置换术比较:一项荟萃分析

Comparison of bipolar hemiarthroplasty and total hip arthroplasty for displaced femoral neck fractures in the healthy elderly: a meta-analysis.

作者信息

Wang Feng, Zhang Haifei, Zhang Zhiyu, Ma Chengbin, Feng Ximin

机构信息

Department of Orthopedics, the Fourth Affiliated Hospital of China Medical University, Chongshan Road, Shenyang, 110032, Liaoning, People's Republic of China.

出版信息

BMC Musculoskelet Disord. 2015 Aug 28;16:229. doi: 10.1186/s12891-015-0696-x.

Abstract

BACKGROUND

Displaced femoral neck fractures (FNFs) in healthy elderly patients have traditionally been managed with hemiarthroplasty (HA) or total hip arthroplasty (THA), with studies suggesting that THA may be the better option. However, it has recently been reported that bipolar HA (BHA) also provides good outcomes, and it is not clear as to whether BHA or THA is most appropriate. The purpose of this study was to conduct a meta-analysis of randomized controlled trials (RCTs) comparing the outcomes of BHA with THA for treating FNF in healthy elderly patients.

METHODS

We searched the following databases from inception to May 2015 for relevant RCTs without language restrictions: PubMed, the Cochrane Central Register of Controlled Trials, Ovid MEDLINE and EMBASE, CINAHL, the China Biological Medicine Database, International Clinical Trials Registry Platform, Current Controlled Trials, and ClinicalTrials.gov. RCTs that met the inclusion criteria were statistically analyzed using the Cochrane review methods.

RESULTS

Eight RCTs were included (total 1,014 patients; 523 had BHA and 491 had THA). The data from included RCTs were divided into four subgroups according to different follow-up durations. The Harris Hip Score after BHA was not different from that after THA in all subgroups. Both reoperation rate and acetabular erosion rate were higher after BHA after more than 4 years, while there was a higher dislocation rate associated with THA within 4 years. THA was more favorable regarding the EQindex-5D and the mobility and pain rate, while BHA was more favorable regarding operating time. No significant differences were found regarding infection rate, general complications, 1-year mortality, blood loss, and length of postoperative hospital stay.

CONCLUSIONS

For healthy elderly patients with displaced FNFs, treatment with BHA led to better outcomes regarding dislocation rate, while THA was better regarding acetabular erosion rate and reoperation rate. When comparing BHA with THA, there were no significant differences in other important outcomes such as Harris Hip Score, infection rate, general complications, and 1-year mortality. Further high-quality RCTs are needed to provide robust evidence and evaluate the treatment options.

摘要

背景

健康老年患者的移位型股骨颈骨折(FNFs)传统上采用半髋关节置换术(HA)或全髋关节置换术(THA)进行治疗,研究表明THA可能是更好的选择。然而,最近有报道称双极HA(BHA)也能取得良好的效果,目前尚不清楚BHA和THA哪种最为合适。本研究的目的是对比较BHA与THA治疗健康老年患者FNF结局的随机对照试验(RCTs)进行荟萃分析。

方法

我们检索了以下数据库自建库至2015年5月的相关RCTs,无语言限制:PubMed、Cochrane对照试验中心注册库、Ovid MEDLINE和EMBASE、CINAHL、中国生物医学数据库、国际临床试验注册平台、当前对照试验和ClinicalTrials.gov。符合纳入标准的RCTs采用Cochrane综述方法进行统计分析。

结果

纳入8项RCTs(共1014例患者;523例行BHA,491例行THA)。根据不同随访时间将纳入RCTs的数据分为四个亚组。所有亚组中,BHA术后的Harris髋关节评分与THA术后无差异。4年以上BHA术后再手术率和髋臼侵蚀率均较高,而4年内THA相关脱位率较高。在EQindex - 5D、活动度和疼痛率方面,THA更具优势,而在手术时间方面,BHA更具优势。在感染率、一般并发症、1年死亡率、失血量和术后住院时间方面未发现显著差异。

结论

对于健康老年移位型FNF患者,BHA治疗在脱位率方面导致更好的结局,而THA在髋臼侵蚀率和再手术率方面更好。比较BHA与THA时,在其他重要结局如Harris髋关节评分、感染率、一般并发症和1年死亡率方面无显著差异。需要进一步的高质量RCTs来提供有力证据并评估治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be65/4552391/c3482f1f1cc1/12891_2015_696_Fig1_HTML.jpg

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