骨髓脂肪生成增强在糖尿病并发症中的病理生理作用。
Pathophysiological role of enhanced bone marrow adipogenesis in diabetic complications.
作者信息
Piccinin Meghan A, Khan Zia A
机构信息
Department of Pathology and Laboratory Medicine; Schulich School of Medicine & Dentistry; University of Western Ontario ; London, ON Canada.
Department of Pathology and Laboratory Medicine; Schulich School of Medicine & Dentistry; University of Western Ontario ; London, ON Canada ; Metabolism and Diabetes Program; Lawson Health Research Institute ; London, ON Canada.
出版信息
Adipocyte. 2014 Dec 10;3(4):263-72. doi: 10.4161/adip.32215. eCollection 2014 Oct-Dec.
Diabetes leads to complications in select organ systems primarily by disrupting the vasculature of the target organs. These complications include both micro- (cardiomyopathy, retinopathy, nephropathy, and neuropathy) and macro-(atherosclerosis) angiopathies. Bone marrow angiopathy is also evident in both experimental models of the disease as well as in human diabetes. In addition to vascular disruption, bone loss and increased marrow adiposity have become hallmarks of the diabetic bone phenotype. Emerging evidence now implicates enhanced marrow adipogenesis and changes to cellular makeup of the marrow in a novel mechanistic link between various secondary complications of diabetes. In this review, we explore the mechanisms of enhanced marrow adipogenesis in diabetes and the link between changes to marrow cellular composition, and disruption and depletion of reparative stem cells.
糖尿病主要通过破坏靶器官的血管系统导致特定器官系统出现并发症。这些并发症包括微血管病变（心肌病、视网膜病变、肾病和神经病变）和大血管病变（动脉粥样硬化）。在该疾病的实验模型以及人类糖尿病患者中，骨髓血管病变也很明显。除了血管破坏外，骨质流失和骨髓脂肪增多已成为糖尿病骨表型的特征。新出现的证据表明，在糖尿病的各种继发性并发症之间，存在一种新的机制联系，即骨髓脂肪生成增强以及骨髓细胞组成发生变化。在这篇综述中，我们探讨了糖尿病中骨髓脂肪生成增强的机制，以及骨髓细胞组成变化与修复性干细胞的破坏和耗竭之间的联系。
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