Nakamura Tomoya, Dinh Trong Ha, Asai Makoto, Nishimaru Hiroshi, Matsumoto Jumpei, Takamura Yusaku, Hori Etsuro, Honda Sokichi, Yamada Hiroshi, Mihara Takuma, Matsumoto Mitsuyuki, Nishijo Hisao
System Emotional Science, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Department of Anatomy, Faculty of Medicine, University of Toyama, Toyama 930-0194, Japan.
Heliyon. 2020 May 27;6(5):e04043. doi: 10.1016/j.heliyon.2020.e04043. eCollection 2020 May.
Human clinical studies reported that several electroencephalographical (EEG) parameters can be used as biomarkers of psychiatric disorders. EEGs recorded from non-human primates (monkeys) is useful for understanding of human pathologies of psychiatric disorders and development of new therapeutic agents.
In this study, we expand a previous non-invasive head holding system with face masks for awake monkeys to be applied to scalp EEG recording. The new design of a head holding system allows to attach scalp EEG electrodes on the positions comparable to human electrode placement and to present auditory stimuli.
With this system, we could record auditory evoked potentials (AEPs) in auditory sensory gating and oddball paradigms, which are often used as biomarkers of psychiatric disorders in animal models and human patients. The recorded AEPs were comparable to previous human clinical data.
Compared with previous non-invasive head holding systems, top, side (cheek and ears), and rear of the head can be open for attachment of EEG electrodes and auditory stimulation in the present system.
The results suggest that the present system is useful in EEG recording from awake monkeys. Furthermore, this system can be applied to eye-tracking and chronic intra-cerebral recording experiments.
人体临床研究报告称，几种脑电图（EEG）参数可作为精神疾病的生物标志物。从非人灵长类动物（猴子）记录的脑电图有助于理解精神疾病的人类病理以及开发新的治疗药物。
在本研究中，我们扩展了先前用于清醒猴子的带有面罩的非侵入性头部固定系统，以应用于头皮脑电图记录。头部固定系统的新设计允许在与人类电极放置位置相当的位置附着头皮脑电图电极，并呈现听觉刺激。
使用该系统，我们能够在听觉感觉门控和Oddball范式中记录听觉诱发电位（AEP），这些范式在动物模型和人类患者中常被用作精神疾病的生物标志物。记录的AEP与先前的人体临床数据相当。
与先前的非侵入性头部固定系统相比，本系统的头部顶部、侧面（脸颊和耳朵）和后部可以打开，以便附着脑电图电极和进行听觉刺激。
结果表明，本系统可用于从清醒猴子记录脑电图。此外，该系统可应用于眼动追踪和慢性脑内记录实验。
