黄斑区布鲁赫膜长度与眼轴长度。北京眼病研究。
Macular Bruch's Membrane Length and Axial Length. The Beijing Eye Study.
作者信息
Jonas Jost B, Wang Ya Xing, Zhang Qi, Liu Yi, Xu Liang, Wei Wen Bin
机构信息
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Germany.
Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Lab, Beijing, China.
出版信息
PLoS One. 2015 Aug 28;10(8):e0136833. doi: 10.1371/journal.pone.0136833. eCollection 2015.
PURPOSE
To assess whether macular Bruch´s membrane gets lengthened in axial myopia.
METHODS
Using the enhanced depth imaging mode of spectral-domain optical coherence tomography and examining a subgroup of participants of the population-based cross-sectional Beijing Eye Study, we measured the length of Bruch´s membrane ("MacBMLength") from the fovea to the temporal edge of parapapillary gamma zone, and the distance between the fovea and the temporal optic disc border. Parapapillary gamma zone was defined as the parapapillary region without Bruch's membrane. We additionally measured ocular biometric parameters and assessed non-ophthalmologic variables.
RESULTS
Measurements of MacBMLength were performed on 322 individuals. MacBMLength (mean: 3.99 ± 0.33 mm; range: 3.17-4.93 mm) was not significantly associated with any systemic parameter or ocular biometric parameter. Gamma zone width (mean: 0.18 ± 0.30 mm; range: 0.00-2.61 mm) was associated (multivariate analysis; correlation coefficient r:0.80) with longer axial length (P<0.001; standardized correlation coefficient beta: 0.60; non-standardized correlation coefficient B:0.11; 95%CI: 0.09,0.14) and with longer fovea-optic disc border distance (P<0.001; beta:0.28; B:0.19; 95%CI:0.14,0.25), but not with MacBMLength (P = 0.42). Fovea-temporal disc border distance (mean: 4.16 ± 0.44 mm; range: 3.17-5.86 mm) was associated (overall correlation coefficient: 0.68) with longer axial length (P<0.001; beta: 0.36; B: 0.10; 95%CI: 0.06, 0.13), after adjusting for flatter anterior chamber depth (P = 0.003; beta:-0.14; B:-0.14; 95%CI: -0.23,-0.05) and wider parapapillary gamma zone (P<0.001; beta:0.42; B:0.62; 95%CI:0.44,0.81).
CONCLUSIONS
In contrast to parapapillary gamma zone width and fovea-disc border distance, MacBMLength was not significantly associated with axial length. Axial elongation associated increase in fovea-disc distance may predominantly occur through development or elongation of parapapillary gamma zone, while macular Bruch´s membrane may mostly be independent of axial elongation.
目的
评估在轴性近视中黄斑区布鲁赫膜是否会变长。
方法
利用频域光学相干断层扫描的增强深度成像模式，对基于人群的横断面北京眼病研究中的一部分参与者进行检查，我们测量了从中央凹到视乳头旁γ区颞侧边缘的布鲁赫膜长度（“黄斑布鲁赫膜长度”），以及中央凹与颞侧视盘边界之间的距离。视乳头旁γ区被定义为没有布鲁赫膜的视乳头旁区域。我们还测量了眼部生物测量参数并评估了非眼科变量。
结果
对322名个体进行了黄斑布鲁赫膜长度的测量。黄斑布鲁赫膜长度（平均值：3.99±0.33毫米；范围：3.17 - 4.93毫米）与任何全身参数或眼部生物测量参数均无显著相关性。γ区宽度（平均值：0.18±0.30毫米；范围：0.00 - 2.61毫米）与更长的眼轴长度相关（多变量分析；相关系数r：0.80）（P<0.001；标准化相关系数β：0.60；非标准化相关系数B：0.11；95%置信区间：0.09，0.14），与更长的中央凹 - 视盘边界距离相关（P<0.001；β：0.28；B：0.19；95%置信区间：0.14，0.25），但与黄斑布鲁赫膜长度无关（P = 0.42）。中央凹 - 颞侧视盘边界距离（平均值：4.16±0.44毫米；范围：3.17 - 5.86毫米）与更长的眼轴长度相关（总体相关系数：0.68）（P<0.001；β：0.36；B：0.10；95%置信区间：0.06，0.13），在调整了较扁平的前房深度（P = 0.003；β： - 0.14；B： - 0.14；95%置信区间： - 0.23， - 0.05）和更宽的视乳头旁γ区（P<0.001；β：0.42；B：0.62；95%置信区间：0.44，0.81）之后。
结论
与视乳头旁γ区宽度和中央凹 - 视盘边界距离不同，黄斑布鲁赫膜长度与眼轴长度无显著相关性。眼轴伸长相关的中央凹 - 视盘距离增加可能主要通过视乳头旁γ区的发育或伸长发生，而黄斑布鲁赫膜可能大多独立于眼轴伸长。
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