Shandong First Medical University, Jinan, Shandong Province, China.
Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province, China.
J Int Med Res. 2021 Jul;49(7):3000605211032780. doi: 10.1177/03000605211032780.
To study the characteristics and relationship between peripapillary retinal nerve fiber layer (RNFL) and choroidal thickness in young people with myopia.
We retrospectively analyzed 92 cases (52 myopia, 40 emmetropia) regarding age, sex, refractive power, axial length (AL), and intraocular pressure. Peripapillary RNFL and choroidal thicknesses were measured by optical coherence tomography (OCT) in six sectors. Differences in thicknesses between the two groups were compared by single-factor analysis.
RNFL was thickest in the inferotemporal sector (157.3 ± 19.66 µm) and thinnest in the nasal sector (58.78 ± 18.41 µm). Peripapillary choroid was thickest in the superonasal sector (176.37 ± 33.92 µm) and thinnest in the inferotemporal sector (131.79 ± 25.22 µm). The RNFL was thinner in the myopia group (99.04 ± 8.23 µm) vs the emmetropia group (103.25 ± 8.32 µm); significantly different in the superotemporal and inferonasal sectors. Peripapillary choroid thickness in the myopia group (148.65 ± 26.64 µm) was lower vs the emmetropia group (160.88 ± 29.06 µm); significantly different in the nasal, inferonasal, and inferotemporal sectors. RNFL thickness was negatively correlated with choroidal thickness in the nasal sector (r = -0.288).
Peripapillary RNFL and choroidal thicknesses showed regional distributions. RNFL was negatively correlated with PCT in the nasal sector, possibly related to eye axis growth and choroidal compensation.
研究年轻人近视患者的视盘周围视网膜神经纤维层（RNFL）和脉络膜厚度的特征及其相关性。
回顾性分析 92 例（近视 52 例，正视 40 例）的年龄、性别、屈光力、眼轴（AL）和眼压。采用光学相干断层扫描（OCT）在 6 个象限测量视盘周围 RNFL 和脉络膜厚度。采用单因素分析法比较两组间厚度的差异。
RNFL 在颞下象限最厚（157.3±19.66μm），鼻侧最薄（58.78±18.41μm）。视盘周围脉络膜在鼻上象限最厚（176.37±33.92μm），颞下象限最薄（131.79±25.22μm）。近视组的 RNFL 较正视组薄（99.04±8.23μm），在颞上和鼻下象限差异有统计学意义。近视组视盘周围脉络膜厚度（148.65±26.64μm）较正视组低（160.88±29.06μm），在鼻侧、鼻下和颞下象限差异有统计学意义。RNFL 厚度与鼻侧脉络膜厚度呈负相关（r=-0.288）。
视盘周围 RNFL 和脉络膜厚度呈区域性分布。RNFL 与鼻侧 PCT 呈负相关，可能与眼球轴长增长和脉络膜代偿有关。
