Xu Ke, Xu Yishuang, Qin Youran, Zhang Yufei, Zheng Hongmei, Chen Changzheng, Su Yu
Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Invest Ophthalmol Vis Sci. 2025 Mar 3;66(3):57. doi: 10.1167/iovs.66.3.57.
To investigate the effects of partial sleep deprivation (PSD) on the retinal microvasculature in individuals with myopia, using optical coherence tomography angiography (OCTA).
In total, 87 right eyes were categorized by axial length (AL) into three groups: A (AL < 24 mm, n = 20), B (24 ≤ AL < 26 mm, n = 41), and C (AL ≥ 26 mm, n = 26). Participants underwent macular (6 mm × 6 mm) and optic disc (4.5 mm × 4.5 mm) OCTA scans. Vessel density (VD) parameters-including superficial capillary plexus VD (SCP-VD), deep capillary plexus VD (DCP-VD), radial peripapillary capillary VD (RPC-VD), inside disc RPC VD (iVD), and peripapillary RPC VD (ppVD)-were compared at baseline, before and after PSD, and following 3 days of regular sleep.
Compared with group A, groups B and C had lower baseline DCP-VD in all subregions (P < 0.05), except for the perifovea-inferior area, where only groups C and A showed significant differences (P = 0.001). After PSD, group C showed a decrease in SCP-VD in certain subregions of the parafovea (P = 0.013 and P = 0.022 for parafovea-temporal and parafovea-inferior, respectively), along with an increase in ppVD (P = 0.012). All VD parameters recovered after 3 days of regular sleep (P < 0.05).
The retinal microvasculature of myopic eyes with an AL of ≥26 mm show greater susceptibility to PSD than those with an AL of <26 mm. However, short-term PSD effects can be restored by setting a regular sleep schedule.
使用光学相干断层扫描血管造影（OCTA）研究部分睡眠剥夺（PSD）对近视个体视网膜微血管系统的影响。
总共87只右眼根据眼轴长度（AL）分为三组：A组（AL < 24 mm，n = 20）、B组（24 ≤ AL < 26 mm，n = 41）和C组（AL ≥ 26 mm，n = 26）。参与者接受黄斑区（6 mm×6 mm）和视盘（4.5 mm×4.5 mm）的OCTA扫描。比较基线、PSD前后以及规律睡眠3天后的血管密度（VD）参数，包括浅表毛细血管丛VD（SCP-VD）、深部毛细血管丛VD（DCP-VD）、放射状视盘周围毛细血管VD（RPC-VD）、视盘内RPC VD（iVD）和视盘周围RPC VD（ppVD）。
与A组相比，B组和C组在所有子区域的基线DCP-VD较低（P < 0.05），除了中央凹下区域，该区域只有C组和A组存在显著差异（P = 0.001）。PSD后，C组在黄斑旁某些子区域的SCP-VD降低（黄斑颞侧和黄斑下分别为P = 0.013和P = 0.022），同时ppVD增加（P = 0.012）。规律睡眠3天后，所有VD参数均恢复（P < 0.05）。
眼轴长度≥26 mm的近视眼睛的视网膜微血管系统比眼轴长度<26 mm的近视眼睛对PSD更敏感。然而，短期PSD的影响可以通过建立规律的睡眠时间表来恢复。
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