Stope M B, Koensgen D, Burchardt M, Concin N, Zygmunt M, Mustea A
Department of Urology, University Medicine Greifswald, Greifswald, Germany.
Department of Gynaecology and Obstetrics, University Medicine Greifswald, Greifswald, Germany.
Crit Rev Oncol Hematol. 2016 Jan;97:152-6. doi: 10.1016/j.critrevonc.2015.08.008. Epub 2015 Aug 13.
Ovarian cancer (OC) is a major problem in gynecological oncology. Options for diagnosis and treatment of advanced stages and thus for patient prognosis have not been improved substantially over the past decades. Heat shock proteins (HSP) are characterized as stress-induced molecular chaperones performing cell survival factor functions. In cancer cells, various crucial and clinically important cell responses are vitally influenced and modulated by HSPs, e.g., cell growth and treatment resistance. Despite the limited knowledge on HSPs in OC progression, their roles as biomarkers, prognostic factors and their drug target properties appears promising for future clinical applications and therapeutic approaches.
卵巢癌（OC）是妇科肿瘤学中的一个主要问题。在过去几十年中，晚期卵巢癌的诊断和治疗选择以及患者预后并未得到实质性改善。热休克蛋白（HSP）被认为是应激诱导的分子伴侣，具有细胞生存因子功能。在癌细胞中，热休克蛋白对各种关键且具有临床重要性的细胞反应产生至关重要的影响和调节作用，例如细胞生长和治疗耐药性。尽管关于热休克蛋白在卵巢癌进展中的了解有限，但它们作为生物标志物、预后因素的作用及其药物靶点特性在未来临床应用和治疗方法中似乎具有广阔前景。
