Petersen Inge, Pedersen Nancy L, Rantanen Taina, Kremen William S, Johnson Wendy, Panizzon Matthew S, Christiansen Lene, Franz Carol E, McGue Matt, Christensen Kaare, Hamdi Nayla R, Krueger Robert F, Reynolds Chandra
The Danish Twin Registry, Epidemiology, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Behav Genet. 2016 Jan;46(1):20-30. doi: 10.1007/s10519-015-9736-4. Epub 2015 Aug 29.
Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34-99 (N = 10,681). Fisher's test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectories.
握力的年龄相关性下降预示着晚年的残疾、虚弱、幸福感降低和认知变化。虽然握力具有遗传性，但基因对握力变化的影响相对被忽视，在一项纵向研究中，非共享环境影响被确定为主要因素。基因与环境的相互作用，尤其是基因-环境相互作用，对握力轨迹的影响程度尚未得到研究。我们在“多研究中基因与环境相互作用”联盟的七项衰老双胞胎研究中考虑了纵向握力测量。对年龄在34-99岁的同性双胞胎对（N = 10,681）估计生长曲线参数。对单卵双胞胎对内差异（N = 1724）的混合分布进行了Fisher检验，以检验生长曲线参数。我们观察到握力轨迹存在显著的基因-环境相互作用。最后，我们比较了不同APOE单倍型生长曲线参数对内差异的变异性。虽然结果没有统计学意义，但结果表明APOEɛ2ɛ2/ɛ2ɛ3单倍型可能缓冲环境对握力轨迹的影响。
