Pedersen Nancy L, Gatz Margaret, Finch Brian K, Finkel Deborah, Butler David A, Dahl Aslan Anna, Franz Carol E, Kaprio Jaakko, Lapham Susan, McGue Matt, Mosing Miriam A, Neiderhiser Jenae, Nygaard Marianne, Panizzon Matthew, Prescott Carol A, Reynolds Chandra A, Sachdev Perminder, Whitfield Keith E
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA.
Twin Res Hum Genet. 2019 Dec;22(6):809-816. doi: 10.1017/thg.2019.76. Epub 2019 Sep 23.
The Interplay of Genes and Environment across Multiple Studies (IGEMS) is a consortium of 18 twin studies from 5 different countries (Sweden, Denmark, Finland, United States, and Australia) established to explore the nature of gene-environment (GE) interplay in functioning across the adult lifespan. Fifteen of the studies are longitudinal, with follow-up as long as 59 years after baseline. The combined data from over 76,000 participants aged 14-103 at intake (including over 10,000 monozygotic and over 17,000 dizygotic twin pairs) support two primary research emphases: (1) investigation of models of GE interplay of early life adversity, and social factors at micro and macro environmental levels and with diverse outcomes, including mortality, physical functioning and psychological functioning; and (2) improved understanding of risk and protective factors for dementia by incorporating unmeasured and measured genetic factors with a wide range of exposures measured in young adulthood, midlife and later life.
跨多研究的基因与环境相互作用（IGEMS）是一个由来自5个不同国家（瑞典、丹麦、芬兰、美国和澳大利亚）的18项双胞胎研究组成的联盟，旨在探索基因-环境（GE）相互作用在整个成年期功能中的本质。其中15项研究是纵向研究，随访时间长达基线后59年。来自超过76000名年龄在14至103岁的参与者（包括超过10000对同卵双胞胎和超过17000对异卵双胞胎）的综合数据支持两个主要研究重点：（1）调查早期生活逆境、微观和宏观环境层面的社会因素以及包括死亡率、身体功能和心理功能在内的多种结果的基因-环境相互作用模型；（2）通过将未测量和已测量的遗传因素与在青年期、中年期和老年期测量的广泛暴露因素相结合，更好地理解痴呆症的风险和保护因素。
