Divala Titus H, Mungwira Randy G, Laufer Miriam K
Blantyre Malaria Project, University of Malawi College of Medicine, Blantyre, Malawi.
Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, USA.
Vaccine. 2015 Nov 25;33(47):6401-5. doi: 10.1016/j.vaccine.2015.08.042. Epub 2015 Aug 25.
Conducting clinical trials to prevent and treat infectious diseases in pregnancy is essential to saving maternal and newborn lives, though it is fraught with challenges. We have been conducting research in malaria treatment and prevention in children and pregnant women in Blantyre, Malawi for over a decade. Here, we review some of the unique challenges that we have faced in leading research studies that with rigor and integrity and maintaining the highest ethical standard. We conclude with concrete strategies to overcome some of the apparent obstacles that frequently focus on building trust through bidirectional communication with local health workers and communities. We also highlight the key role of local and international investigators to advocate for the health of the communities in which they work.
开展预防和治疗孕期传染病的临床试验对于拯救孕产妇和新生儿生命至关重要，尽管这充满挑战。在过去十多年里，我们一直在马拉维布兰太尔针对儿童和孕妇开展疟疾治疗与预防方面的研究。在此，我们回顾在严谨、诚信地开展研究并维持最高道德标准的过程中所面临的一些独特挑战。我们最后提出具体策略，以克服一些常见的明显障碍，这些策略通常侧重于通过与当地卫生工作者和社区进行双向沟通来建立信任。我们还强调了当地和国际研究人员在倡导其工作所在社区健康方面的关键作用。
