Nasrallah Rania, Hassouneh Ramzi, Hébert Richard L
Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Department of Cellular and Molecular Medicine, Kidney Research Centre, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Am Soc Nephrol. 2016 Mar;27(3):666-76. doi: 10.1681/ASN.2015050528. Epub 2015 Aug 28.
An important measure of cardiovascular health is obtained by evaluating the global cardiovascular risk, which comprises a number of factors, including hypertension and type 2 diabetes, the leading causes of illness and death in the world, as well as the metabolic syndrome. Altered immunity, inflammation, and oxidative stress underlie many of the changes associated with cardiovascular disease, diabetes, and the metabolic syndrome, and recent efforts have begun to elucidate the contribution of PGE2 in these events. This review summarizes the role of PGE2 in kidney disease outcomes that accelerate cardiovascular disease, highlights the role of cyclooxygenase-2/microsomal PGE synthase 1/PGE2 signaling in hypertension and diabetes, and outlines the contribution of PGE2 to other aspects of the metabolic syndrome, particularly abdominal adiposity, dyslipidemia, and atherogenesis. A clearer understanding of the role of PGE2 could lead to new avenues to improve therapeutic options and disease management strategies.
评估全球心血管风险是衡量心血管健康的一项重要指标，全球心血管风险包含多个因素，包括高血压和2型糖尿病（全球疾病和死亡的主要原因）以及代谢综合征。免疫、炎症和氧化应激的改变是许多与心血管疾病、糖尿病和代谢综合征相关变化的基础，最近的研究已开始阐明前列腺素E2（PGE2）在这些事件中的作用。本综述总结了PGE2在加速心血管疾病的肾脏疾病结局中的作用，强调了环氧化酶-2/微粒体PGE合酶1/PGE2信号通路在高血压和糖尿病中的作用，并概述了PGE2对代谢综合征其他方面的影响，特别是腹部肥胖、血脂异常和动脉粥样硬化的形成。更清楚地了解PGE2的作用可能会带来改善治疗选择和疾病管理策略的新途径。
