Günther V, Bauer I, Hedderich J, Mettler L, Schubert M, Mackelenbergh M T van, Maass N, Alkatout I
Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 24, 24105 Kiel, Germany.
Department of Gynecology and Obstetrics, University Hospitals Schleswig-Holstein, Campus Kiel, Arnold-Heller Str. 3, House 24, 24105 Kiel, Germany.
Eur J Obstet Gynecol Reprod Biol. 2015 Nov;194:38-42. doi: 10.1016/j.ejogrb.2015.08.007. Epub 2015 Aug 17.
Is the saliva test, Geratherm ovu control, as accurate as the established urinary luteinizing hormone (LH) test for detecting ovulation and the following the fertile period?
The voluntary participants were 74 healthy women with regular menstrual cycles and not using any hormonal contraceptives. The women used Geratherm ovu control, a small plastic hand-held microscope, for detecting the fertile period. A drop of saliva from sublingual was put onto the lens of the microscope. Three results were possible: non-fertile (dot pattern), transitional and fertile (ferning pattern). The participants performed the saliva test from the 5th till the 22nd day of the menstrual cycle and noted the respective result in a table. In addition to Geratherm ovu control, the EXACTO test for determining urinary LH concentration and the time of peak fertility was also performed.
Positive LH shows a sharp increase beginning on the 10th cycle day with a maximum on the 17th cycle day. The curve for positive saliva and questionable positive saliva (one curve) is almost parallel with the curve for positive LH, reaching a maximum on the 16th cycle day. There is a high level of conformity for the same test results from the 5th (100%) till the 14th (84%) cycle day and from the 18th (80%) till the 22nd (96%) cycle day which corresponds to the pre- and post-ovulatory period.
The saliva and the LH test both detect the fertile window of a menstrual cycle. Caused by the different hormones (estrogen for the saliva and LH for the LH test) leading to the respective positive test results, saliva turns positive 24h before LH. Consequently, the saliva test can be used as an ovulation test and help women maximize their chances of conceiving. There is also a high congruence between LH and saliva in the pre- and post-ovulatory period, indicating that the saliva test can also be used for contraception purposes.
用于检测排卵及监测排卵期的唾液检测产品“杰诺 Therm 排卵监测仪”，其准确性是否与已确立的尿促黄体生成素（LH）检测相当？
74 名月经周期规律且未使用任何激素避孕方法的健康女性自愿参与研究。这些女性使用杰诺 Therm 排卵监测仪（一种小型塑料手持显微镜）来检测排卵期。将一滴舌下唾液滴在显微镜镜片上。可能出现三种结果：非排卵期（点状图案）、过渡期和排卵期（蕨状图案）。参与者在月经周期的第 5 天至第 22 天进行唾液检测，并将各自的结果记录在表格中。除了使用杰诺 Therm 排卵监测仪外，还进行了用于测定尿 LH 浓度及排卵高峰期时间的 EXACTO 检测。
LH 阳性结果显示从月经周期第 10 天开始急剧上升，在第 17 天达到峰值。阳性唾液和可疑阳性唾液（一条曲线）的曲线与 LH 阳性曲线几乎平行，在第 16 天达到峰值。从月经周期第 5 天（100%）到第 14 天（84%）以及从第 18 天（80%）到第 22 天（96%），相同检测结果的符合度较高，这分别对应排卵前和排卵后时期。
唾液检测和 LH 检测均能检测出月经周期中的排卵期。由于导致各自阳性检测结果的激素不同（唾液检测为雌激素，LH 检测为 LH），唾液在 LH 之前 24 小时呈阳性。因此，唾液检测可作为一种排卵检测方法，帮助女性最大化受孕几率。在排卵前和排卵后时期，LH 和唾液检测结果也具有高度一致性，这表明唾液检测也可用于避孕目的。
